Gene name: PTK2
Protein name: Focal adhesion kinase
List of molecules and drugs that interact with protein Q05397
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q05397_0O7 | 0O7 | n/a | 71568837 | CHEMBL2333445 | 8-(4-ethylphenyl)-5-methyl-2,5-dihydropyrazolo[4,3-c][2,1]benzothiazine 4,4-dioxide | n/a | |
| 2 | Q05397_0PF | 0PF | n/a | 71578921 | CHEMBL2333436 | 1-ethyl-8-(4-ethylphenyl)-5-methyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazine 4,4-dioxide | n/a | |
| 3 | Q05397_10N | 10N | n/a | 71277531 | CHEMBL2315579 | N-(3-{[(5-cyano-2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)amino]methyl}pyridin-2-yl)-N-methylmethanesulfonamide | n/a | |
| 4 | Q05397_1BQ | 1BQ | n/a | 70789288 | CHEMBL2333434 | [4-(2-hydroxyethyl)piperidin-1-yl][4-(5-methyl-4,4-dioxido-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-yl)phenyl]methanone | n/a | |
| 5 | Q05397_1BR | 1BR | n/a | 70698427 | CHEMBL2333444 | N-(4-tert-butylbenzyl)-1,5-dimethyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-amine 4,4-dioxide | n/a | |
| 6 | Q05397_30G | 30G | n/a | 3071991 | CHEMBL1968515 | 3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1H)-one | n/a | |
| 7 | Q05397_4GU | 4GU | n/a | 42226831 | CHEMBL2315560 | N-(2-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | n/a | |
| 8 | Q05397_4KA | 4KA | n/a | 6400924 | CHEMBL1599242 | 3-methyl-1,5-dihydropyrazolo[4,3-c]pyrazole | n/a | |
| 9 | Q05397_7PY | 7PY | DB07248 | 11957393 | CHEMBL205098 | 7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE | n/a | IC50(nM) = 200.0 |
| 10 | Q05397_7QB | 7QB | n/a | 156600270 | CHEMBL5285810 | (2S,4R)-4-hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide | n/a | |
| 11 | Q05397_ADP | ADP | DB16833 | 6022 | CHEMBL14830 | ADENOSINE-5'-DIPHOSPHATE | n/a | |
| 12 | Q05397_ATP | ATP | DB00171 | 5957 | CHEMBL14249 | ADENOSINE-5'-TRIPHOSPHATE | n/a | |
| 13 | Q05397_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 14 | Q05397_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 15 | Q05397_H82 | H82 | n/a | 137332108 | n/a | 3-methoxy-~{N}-(1-methylpiperidin-1-ium-4-yl)-4-[[4-[(3-oxidanylidene-1,2-dihydroinden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide | n/a | |
| 16 | Q05397_IPA | IPA | DB02325 | 3776 | CHEMBL582 | ISOPROPYL ALCOHOL | n/a | |
| 17 | Q05397_K8A | K8A | n/a | 4173761 | CHEMBL2425111 | 3-bromo-5-(2H-tetrazol-5-yl)pyridine | n/a | |
| 18 | Q05397_K9Y | K9Y | n/a | 15945881 | CHEMBL2425144 | 1-[4-(6-amino-9H-purin-9-yl)phenyl]-3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea | n/a | |
| 19 | Q05397_KAO | KAO | n/a | 71695585 | CHEMBL2425156 | 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[4-(pyridin-3-yl)phenyl]urea | n/a | |
| 20 | Q05397_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 21 | Q05397_P1E | P1E | DB08341 | 25920890 | CHEMBL509485 | 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide | n/a | IC50(nM) = 3800.0 |
| 22 | Q05397_P4N | P4N | n/a | 11612883 | CHEMBL514554 | 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1~{H}-quinolin-2-one | n/a | |
| 23 | Q05397_P7N | P7N | n/a | 11706305 | n/a | ~{N}-methyl-~{N}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{H}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | n/a | |
| 24 | Q05397_P9K | P9K | n/a | n/a | n/a | N-Methyl-N-(2-{[2-(2-oxo-2,3-dihydro-1H-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | n/a | |
| 25 | Q05397_PEG | PEG | n/a | 8117 | CHEMBL1235226 | DI(HYDROXYETHYL)ETHER | n/a | |
| 26 | Q05397_PKE | PKE | n/a | 155804476 | n/a | ~{N}-methyl-~{N}-[3-[[[2-[(2-oxidanylidene-1,3-dihydroindol-5-yl)amino]pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | n/a | |
| 27 | Q05397_PVT | PVT | n/a | 10318783 | n/a | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | n/a | |
| 28 | Q05397_Q2H | Q2H | n/a | n/a | n/a | ~{N}-methyl-~{N}-[3-[(~{E})-[2-phenylazanyl-5-(trifluoromethyl)pyrimidin-4-yl]iminomethyl]pyridin-2-yl]methanesulfonamide | n/a | |
| 29 | Q05397_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 30 | Q05397_YAM | YAM | n/a | 11713159 | CHEMBL1084546 | N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide | n/a | |
| 31 | Q05397_ZN | ZN | n/a | 32051 | CHEMBL1236970 | ZINC ION | n/a | |
| 32 | Q05397_BI9 | BI9 | DB07460 | 9934347 | CHEMBL458997 | 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE | n/a | IC50(nM) = 4.5 |
| 33 | Q05397_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |