Gene name: PTK2B
Protein name: Protein-tyrosine kinase 2-beta
List of molecules and drugs that interact with protein Q14289
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q14289_0YH | 0YH | n/a | 70678491 | CHEMBL2207431 | 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[3-(4-methoxy-2-methylphenyl)-1H-pyrazol-5-yl]urea | n/a | |
| 2 | Q14289_0YJ | 0YJ | n/a | 70678492 | CHEMBL2207427 | 7-({[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]carbamoyl}amino)-N-(propan-2-yl)-1H-indole-2-carboxamide | n/a | |
| 3 | Q14289_349 | 349 | n/a | 42615255 | n/a | 5-{[4-{[2-(pyrrolidin-1-ylsulfonyl)benzyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,3-dihydro-2H-indol-2-one | n/a | |
| 4 | Q14289_3JZ | 3JZ | n/a | 11598628 | CHEMBL472212 | N-methyl-N-{2-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]phenyl}methanesulfonamide | n/a | |
| 5 | Q14289_4JZ | 4JZ | n/a | n/a | n/a | 1-[5-tert-butyl-2-(4-methylphenyl)-1,2-dihydro-3H-pyrazol-3-ylidene]-3-{3-[(pyridin-3-yloxy)methyl]-1H-pyrazol-5-yl}urea | n/a | |
| 6 | Q14289_7FM | 7FM | n/a | 134130812 | CHEMBL3889951 | 25-(methylsulfonyl)-8-(trifluoromethyl)-5,17,18,21,22,23,24,25-octahydro-12H-7,11-(azeno)-16,13-(metheno)pyrido[3,2-i]pyrrolo[1,2-q][1,3,7,11,17]pentaazacyclohenicosin-20(6H)-one | n/a | |
| 7 | Q14289_AGS | AGS | DB02930 | 440317;444377; | CHEMBL131890 | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | n/a | |
| 8 | Q14289_B96 | B96 | DB03044 | 156422 | CHEMBL103667 | 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA | n/a | IC50(nM) = 400.0 Kd(nM) = 990.0 |
| 9 | Q14289_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 10 | Q14289_MG | MG | n/a | 888 | n/a | MAGNESIUM ION | n/a | |
| 11 | Q14289_P1E | P1E | DB08341 | 25920890 | CHEMBL509485 | 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide | n/a | IC50(nM) = 88.0 |
| 12 | Q14289_PO4 | PO4 | DB14523 | 1061 | n/a | PHOSPHATE ION | n/a | |
| 13 | Q14289_SO4 | SO4 | DB14546 | 1117 | n/a | SULFATE ION | n/a | |
| 14 | Q14289_YAM | YAM | n/a | 11713159 | CHEMBL1084546 | N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide | n/a | |
| 15 | Q14289_DB01097 | n/a | DB01097 | n/a | n/a | Leflunomide | antagonist | |
| 16 | Q14289_GEN | GEN | DB01645 | 5280961 | CHEMBL44 | Genistein | n/a | |
| 17 | Q14289_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |