Gene name: MELK
Protein name: Maternal embryonic leucine
List of molecules and drugs that interact with protein Q14680
| # | DrugDomain Data | PBD ligand | DrugBank Accession | PubChem | ChEMBL | Name | Drug action | Affinity data |
|---|---|---|---|---|---|---|---|---|
| 1 | Q14680_0V0 | 0V0 | n/a | 85325331 | n/a | (2-ethoxy-4-{[3-(isoquinolin-7-yl)prop-2-yn-1-yl]oxy}phenyl)methanaminium | n/a | |
| 2 | Q14680_1WS | 1WS | n/a | 71660630 | n/a | N-(3-aminopropyl)-8-[(3-fluorophenyl)amino]-2,4,5,7-tetrahydropyrazolo[3,4-e]indazole-3-carboxamide | n/a | |
| 3 | Q14680_3I7 | 3I7 | n/a | 78673828 | n/a | 3-[2-(phenylcarbamoyl)-5-(1H-pyrazol-4-yl)phenoxy]propan-1-aminium | n/a | |
| 4 | Q14680_45R | 45R | n/a | 78673830 | n/a | 7-{[2-methoxy-4-(1H-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1H-3-benzazepinium | n/a | |
| 5 | Q14680_47W | 47W | n/a | 85325329 | n/a | 1-(4-{[3-(isoquinolin-7-yl)prop-2-yn-1-yl]oxy}-2-methoxybenzyl)piperazinediium | n/a | |
| 6 | Q14680_5QM | 5QM | n/a | 78350469 | CHEMBL3355067 | 3-(isoquinolin-7-yl)prop-2-yn-1-ol | n/a | |
| 7 | Q14680_5U5 | 5U5 | n/a | 54577344 | CHEMBL3699142 | 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide | n/a | |
| 8 | Q14680_6BB | 6BB | n/a | 119058126 | CHEMBL3822876 | 4-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]-3-[(piperidin-4-yl)methoxy]pyridine | n/a | |
| 9 | Q14680_6BE | 6BE | n/a | 119058125 | CHEMBL3823918 | 1-methyl-4-(4-{4-[3-(2-methylpropoxy)pyridin-4-yl]-1H-pyrazol-1-yl}phenyl)piperazine | n/a | |
| 10 | Q14680_6BF | 6BF | n/a | 119058124 | CHEMBL3824068 | 1-methyl-4-[4-(4-{3-[(piperidin-4-yl)methoxy]pyridin-4-yl}-1H-pyrazol-1-yl)phenyl]piperazine | n/a | |
| 11 | Q14680_6BJ | 6BJ | n/a | 3685259 | CHEMBL3823306 | N-[(pyridin-2-yl)methyl]-4-[4-(pyridin-4-yl)-1H-pyrazol-1-yl]benzamide | n/a | |
| 12 | Q14680_6PV | 6PV | n/a | 124219455 | n/a | 4-{2-[(3-methoxyphenyl)amino]-4-[(piperidin-4-yl)methoxy]pyrimidin-5-yl}-N-[2-oxo-2-(phenylamino)ethyl]benzamide | n/a | |
| 13 | Q14680_6Z7 | 6Z7 | n/a | 78350435 | n/a | 7-({4-[(3-hydroxy-5-methoxyphenyl)amino]benzoyl}amino)-1,2,3,4-tetrahydroisoquinolinium | n/a | |
| 14 | Q14680_7KC | 7KC | DB11775 | 25227462 | CHEMBL3128043 | PF-3758309 | n/a | |
| 15 | Q14680_7KD | 7KD | DB12282 | 25117126 | CHEMBL3137331 | ~{N}-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide | n/a | |
| 16 | Q14680_7LV | 7LV | n/a | n/a | n/a | 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one | n/a | |
| 17 | Q14680_7LY | 7LY | n/a | 131801427 | n/a | 2-(benzyloxy)-4-(1H-pyrazol-4-yl)-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide | n/a | |
| 18 | Q14680_7MY | 7MY | n/a | 71725150 | CHEMBL5305160 | 7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-2-({3-[(pyrrolidin-1-yl)methyl]phenyl}amino)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one | n/a | |
| 19 | Q14680_82B | 82B | n/a | 71660629 | n/a | 3'-{[(4-bromo-1-methyl-1H-pyrrol-2-yl)carbonyl]amino}-N-[(1S)-1-phenyl-2-(pyrrolidin-1-yl)ethyl]-1',4'-dihydro-5'H-spiro[cyclopropane-1,6'-pyrrolo[3,4-c]pyrazole]-5'-carboxamide | n/a | |
| 20 | Q14680_ANP | ANP | n/a | 33113 | CHEMBL1230989 | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | n/a | |
| 21 | Q14680_B5S | B5S | n/a | 78350470 | n/a | 3-{5-[(3-hydroxy-5-methoxyphenyl)amino]-2-(phenylcarbamoyl)phenoxy}propan-1-aminium | n/a | |
| 22 | Q14680_CL | CL | n/a | 312 | n/a | CHLORIDE ION | n/a | |
| 23 | Q14680_DMS | DMS | DB01093 | 679 | CHEMBL504 | DIMETHYL SULFOXIDE | n/a | |
| 24 | Q14680_EDO | EDO | n/a | 174 | CHEMBL457299 | 1,2-ETHANEDIOL | n/a | |
| 25 | Q14680_F7D | F7D | n/a | 132471863 | n/a | (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7-methyl-5,8-di(prop-2-yn-1-yl)-7,8-dihydropteridin-6(5H)-one | n/a | |
| 26 | Q14680_GOL | GOL | DB09462 | 753 | CHEMBL692 | GLYCEROL | n/a | |
| 27 | Q14680_H91 | H91 | n/a | n/a | n/a | 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3,4-dihydropyrimido[5,4-c]quinolin-2(1H)-one | n/a | |
| 28 | Q14680_KSA | KSA | DB02152 | 3035817 | CHEMBL281948 | K-252A | n/a | |
| 29 | Q14680_NA | NA | n/a | 923 | n/a | SODIUM ION | n/a | |
| 30 | Q14680_NF5 | NF5 | n/a | 78350438 | CHEMBL3355057 | 4-bromo-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide | n/a | |
| 31 | Q14680_QBB | QBB | n/a | 63901349 | CHEMBL3355053 | 4-fluoro-N-(1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide | n/a | |
| 32 | Q14680_UNX | UNX | n/a | |||||
| 33 | Q14680_XIN | XIN | DB09079 | 9809715 | CHEMBL502835 | methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate | n/a | |
| 34 | Q14680_TAK | TAK | DB08597 | 11524144 | CHEMBL478629 | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | n/a | |
| 35 | Q14680_2RC | 2RC | DB12010 | 11671467 | CHEMBL2103830 | Fostamatinib | inhibitor |