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2-[({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)methyl]benzoic acid

A0A0S4TER9 — Bifunctional dihydrofolate reductase-thymidylate synthase

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand OF4

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand OF4

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
A0A0S4TER9n/a6pfaOF4A603e6pfaA2Thymidylate synthase/dCMP hydroxymethylaseThymidylate synthase/dCMP hydroxymethylaseThymidylate synthase/dCMP hydroxymethylaseThymidylat_synt
A0A0S4TER9n/a6pfaOF4B603e6pfaB1Thymidylate synthase/dCMP hydroxymethylaseThymidylate synthase/dCMP hydroxymethylaseThymidylate synthase/dCMP hydroxymethylaseThymidylat_synt
A0A0S4TER9n/a6pfaOF4C603e6pfaC2Thymidylate synthase/dCMP hydroxymethylaseThymidylate synthase/dCMP hydroxymethylaseThymidylate synthase/dCMP hydroxymethylaseThymidylat_synt
A0A0S4TER9n/a6pfaOF4D603e6pfaD1Thymidylate synthase/dCMP hydroxymethylaseThymidylate synthase/dCMP hydroxymethylaseThymidylate synthase/dCMP hydroxymethylaseThymidylat_synt
A0A0S4TER9n/a6pfaOF4E603e6pfaE2Thymidylate synthase/dCMP hydroxymethylaseThymidylate synthase/dCMP hydroxymethylaseThymidylate synthase/dCMP hydroxymethylaseThymidylat_synt