(4~{S})-4-[(2~{R})-3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl(phosphonooxy)phosphoryl]oxyethyl]-2~{H}-1,3-thiazol-2-yl]-4-[ethoxy(oxidanyl)phosphoryl]-4-oxidanyl-butanoic acid

A0R2B1 — Multifunctional 2-oxoglutarate metabolism enzyme

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand ZP1

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand ZP1

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
A0R2B1	n/a	6r2a	ZP1	A	2001	e6r2aA2	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	E1_dh
A0R2B1	n/a	6r2a	ZP1	A	2001	e6r2aB2	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
A0R2B1	n/a	6r2a	ZP1	B	2001	e6r2aA2	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	E1_dh
A0R2B1	n/a	6r2a	ZP1	B	2001	e6r2aA3	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
A0R2B1	n/a	6r2a	ZP1	B	2001	e6r2aB3	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	E1_dh
A0R2B1	n/a	6r2d	ZP1	A	2001	e6r2dA3	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	E1_dh
A0R2B1	n/a	6r2d	ZP1	A	2001	e6r2dB3	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
A0R2B1	n/a	6r2d	ZP1	B	2001	e6r2dA1	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
A0R2B1	n/a	6r2d	ZP1	B	2001	e6r2dA3	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	E1_dh
A0R2B1	n/a	6r2d	ZP1	B	2001	e6r2dB2	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	E1_dh
A0R2B1	n/a	6r2d	ZP1	C	2001	e6r2dC2	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	E1_dh
A0R2B1	n/a	6r2d	ZP1	C	2001	e6r2dD1	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
A0R2B1	n/a	6r2d	ZP1	D	2001	e6r2dC1	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
A0R2B1	n/a	6r2d	ZP1	D	2001	e6r2dD3	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	E1_dh