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5-[3-[(4~{S})-6-azanyl-5-cyano-3-methyl-4-propan-2-yl-2~{H}-pyrano[2,3-c]pyrazol-4-yl]-5-cyano-phenyl]-~{N},~{N}-dimethyl-thiophene-2-sulfonamide

A5K8L9 — glycine hydroxymethyltransferase

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand G45

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand G45

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
A5K8L9n/a5gvkG45A502e5gvkA1C-terminal domain in some PLP-dependent transferasesC-terminal domain in some PLP-dependent transferasesC-terminal domain in some PLP-dependent transferasesSHMT
A5K8L9n/a5gvkG45A502e5gvkA2PLP-dependent transferasesPLP-dependent transferasesPLP-dependent transferasesSHMT
A5K8L9n/a5gvkG45A502e5gvkB3PLP-dependent transferasesPLP-dependent transferasesPLP-dependent transferasesSHMT
A5K8L9n/a5gvkG45B502e5gvkA2PLP-dependent transferasesPLP-dependent transferasesPLP-dependent transferasesSHMT
A5K8L9n/a5gvkG45B502e5gvkB2C-terminal domain in some PLP-dependent transferasesC-terminal domain in some PLP-dependent transferasesC-terminal domain in some PLP-dependent transferasesSHMT
A5K8L9n/a5gvkG45B502e5gvkB3PLP-dependent transferasesPLP-dependent transferasesPLP-dependent transferasesSHMT
A5K8L9n/a5gvkG45C502e5gvkC2C-terminal domain in some PLP-dependent transferasesC-terminal domain in some PLP-dependent transferasesC-terminal domain in some PLP-dependent transferasesSHMT
A5K8L9n/a5gvkG45C502e5gvkC3PLP-dependent transferasesPLP-dependent transferasesPLP-dependent transferasesSHMT