4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-N-[2-(piperazin-1-yl)ethyl]-2-(trifluoromethyl)aniline

A7ZUK1 — DNA-directed RNA polymerase subunit beta

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand 42U

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand 42U

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
A7ZUK1	n/a	4xsz	42U	C	1401	e4xszC3	barrel domain in beta subunit of DNA dependent RNA-polymerase	barrel domain in beta subunit of DNA dependent RNA-polymerase	barrel domain in beta subunit of DNA dependent RNA-polymerase	RNA_pol_Rpb2_45
A7ZUK1	n/a	4xsz	42U	C	1401	e4xszC4	N-terminal domain in beta subunit of DNA dependent RNA-polymerase	N-terminal domain in beta subunit of DNA dependent RNA-polymerase	N-terminal domain in beta subunit of DNA dependent RNA-polymerase	RNA_pol_Rpb2_1,RNA_pol_Rpb2_3
A7ZUK1	n/a	4xsz	42U	C	1401	e4xszC9	insertion domain in beta subunit of DNA dependent RNA-polymerase	insertion domain in beta subunit of DNA dependent RNA-polymerase	insertion domain in beta subunit of DNA dependent RNA-polymerase	RNA_pol_Rpb2_2
A7ZUK1	n/a	4xsz	42U	I	1401	e4xszI5	barrel domain in beta subunit of DNA dependent RNA-polymerase	barrel domain in beta subunit of DNA dependent RNA-polymerase	barrel domain in beta subunit of DNA dependent RNA-polymerase	RNA_pol_Rpb2_45
A7ZUK1	n/a	4xsz	42U	I	1401	e4xszI6	N-terminal domain in beta subunit of DNA dependent RNA-polymerase	N-terminal domain in beta subunit of DNA dependent RNA-polymerase	N-terminal domain in beta subunit of DNA dependent RNA-polymerase	RNA_pol_Rpb2_1,RNA_pol_Rpb2_3
A7ZUK1	n/a	4xsz	42U	I	1401	e4xszI7	insertion domain in beta subunit of DNA dependent RNA-polymerase	insertion domain in beta subunit of DNA dependent RNA-polymerase	insertion domain in beta subunit of DNA dependent RNA-polymerase	RNA_pol_Rpb2_2