DrugDomain logoDrugDomain

[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] 2-methyl-2-oxidanyl-propanoate

I3VE75 — 2-hydroxyisobutyryl-CoA synthetase

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand 8LE

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand 8LE

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
I3VE75n/a6hdw8LEA1001e6hdwA1Rossmann-like domain in Acetyl-CoA synthetase-like proteinsRossmann-like domain in Acetyl-CoA synthetase-like proteinsRossmann-like domain in Acetyl-CoA synthetase-like proteinsAMP-binding
I3VE75n/a6hdw8LEA1001e6hdwA2Alpha-lytic protease prodomain-likea+b domain in acetyl-CoA synthetase-like proteinsa+b domain in acetyl-CoA synthetase-like proteinsAMP-binding_C_2
I3VE75n/a6hdw8LEA1001e6hdwA3beta-barrel domain in acetyl-CoA synthetase-like proteinsbeta-barrel domain in acetyl-CoA synthetase-like proteinsbeta-barrel domain in acetyl-CoA synthetase-like proteinsn/a
I3VE75n/a6he08LEA1001e6he0A1Alpha-lytic protease prodomain-likea+b domain in acetyl-CoA synthetase-like proteinsa+b domain in acetyl-CoA synthetase-like proteinsAMP-binding_C_2
I3VE75n/a6he08LEA1001e6he0A2Rossmann-like domain in Acetyl-CoA synthetase-like proteinsRossmann-like domain in Acetyl-CoA synthetase-like proteinsRossmann-like domain in Acetyl-CoA synthetase-like proteinsAMP-binding
I3VE75n/a6he08LEA1001e6he0A3beta-barrel domain in acetyl-CoA synthetase-like proteinsbeta-barrel domain in acetyl-CoA synthetase-like proteinsbeta-barrel domain in acetyl-CoA synthetase-like proteinsn/a
I3VE75n/a6he28LEA502e6he2A1beta-barrel domain in acetyl-CoA synthetase-like proteinsbeta-barrel domain in acetyl-CoA synthetase-like proteinsbeta-barrel domain in acetyl-CoA synthetase-like proteinsn/a
I3VE75n/a6he28LEA502e6he2A2Alpha-lytic protease prodomain-likea+b domain in acetyl-CoA synthetase-like proteinsa+b domain in acetyl-CoA synthetase-like proteinsAMP-binding_C_2
I3VE75n/a6he28LEA502e6he2A3Rossmann-like domain in Acetyl-CoA synthetase-like proteinsRossmann-like domain in Acetyl-CoA synthetase-like proteinsRossmann-like domain in Acetyl-CoA synthetase-like proteinsAMP-binding
I3VE75n/a6he28LEB502e6he2B1beta-barrel domain in acetyl-CoA synthetase-like proteinsbeta-barrel domain in acetyl-CoA synthetase-like proteinsbeta-barrel domain in acetyl-CoA synthetase-like proteinsn/a
I3VE75n/a6he28LEB502e6he2B2Rossmann-like domain in Acetyl-CoA synthetase-like proteinsRossmann-like domain in Acetyl-CoA synthetase-like proteinsRossmann-like domain in Acetyl-CoA synthetase-like proteinsAMP-binding
I3VE75n/a6he28LEB502e6he2B3Alpha-lytic protease prodomain-likea+b domain in acetyl-CoA synthetase-like proteinsa+b domain in acetyl-CoA synthetase-like proteinsAMP-binding_C_2