[6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate

O14920 — Inhibitor of nuclear factor kappa-B kinase subunit beta

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand DB12010

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
O14920	DB12010	2RC	nD1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase, Pkinase_fungal
O14920	DB12010	2RC	nD3	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	IKBKB_SDD

Show other predicted domains (24)

PDB ID	Domain Name	ECOD ID	X Group	H Group	T Group	F Group
4E3C	e4e3cB1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4e3cA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4e3cC1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4e3cD1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4e3cE1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4e3cF1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4e3cB2	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4e3cA3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4e3cC3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4e3cD3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4e3cE3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4e3cF3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4e3cB3	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
	e4e3cA2	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
	e4e3cC2	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
	e4e3cD2	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
	e4e3cE2	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
	e4e3cF2	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
4KIK	e4kikB1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4kikA5	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4kikB3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4kikA4	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
	e4kikB2	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1
	e4kikA6	4177.2.1	BAR/IMD domain-like	Inhibitor of kappaB kinase beta dimerization domain	Inhibitor of kappaB kinase beta dimerization domain	TBK1_CCD1

ECOD domains from experimental PDB structures interacting with ligand DB12010

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
No experimental ECOD data found