[6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate

O75460 — Serine/threonine-protein kinase/endoribonuclease IRE1

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand DB12010

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
O75460	DB12010	2RC	nD3	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
O75460	DB12010	2RC	nD4	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	Ribonuc_2-5A

Show other predicted domains (46)

PDB ID	Domain Name	ECOD ID	X Group	H Group	T Group	F Group
2HZ6	e2hz6A1	5.1.12	beta-propeller-like	beta-propeller	PERK and Ire1 luminal domains	PQQ_2
3P23	e3p23D1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e3p23B1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e3p23A1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e3p23C1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e3p23D2	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
	e3p23B2	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
	e3p23A2	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
	e3p23C2	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
4U6R	e4u6rA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
4U6R	e4u6rA2	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
4YZ9	e4yz9A1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4yz9B1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4yz9C2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4yz9A2	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
	e4yz9B2	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
	e4yz9C1	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
4YZC	e4yzcA2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4yzcB1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4yzcA1	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
	e4yzcB2	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
4YZD	e4yzdA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4yzdB2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4yzdC2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4yzdA2	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
	e4yzdB1	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
	e4yzdC1	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
4Z7G	e4z7gA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4z7gB2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4z7gA2	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
	e4z7gB1	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
4Z7H	e4z7hA2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4z7hB2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e4z7hA1	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
	e4z7hB1	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
5HGI	e5hgiA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
5HGI	e5hgiA2	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
6HV0	e6hv0A1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
6HV0	e6hv0A2	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
6HX1	e6hx1A2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
6HX1	e6hx1A1	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
6SHC	e6shcA1	5.1.12	beta-propeller-like	beta-propeller	PERK and Ire1 luminal domains	PQQ_2
6URC	e6urcA2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e6urcB2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e6urcA1	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like
	e6urcB1	601.7.1	Four-helical up-and-down bundle	HEPN	Nucleotidyltransferase substrate binding subunit/domain	HepT-like

ECOD domains from experimental PDB structures interacting with ligand DB12010

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
No experimental ECOD data found