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5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine

P00374 — Dihydrofolate reductase

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Attributes

UniProt ID
P00374
Protein Name
Dihydrofolate reductase
Ligand Name
5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
DrugBank ID
DB07140
PDB Ligand Accession
53R
ChEMBL ID
CHEMBL459177
PubChem ID
25093369
InChIKey
JPENSYBRTSIYGO-AWEZNQCLSA-N
SMILES
Cc1c(c(nc(n1)N)N)C#CC(C)c2cc(cc(c2)OC)c3ccccc3
Drug Action
n/a
Affinity Metrics
ic50:1360 nM