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P00374

DHFR — Dihydrofolate reductase

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Lists of molecules and drugs that interact with protein P00374
DrugDomain DataDrugBank IDPDB LigandLigand NameChEMBLPubChemInChIKey
ExploreDB00157NAI
1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE
CHEMBL1234616439153BOPGDPNILDQYTO-NNYOXOHSSA-N
ExploreDB00158FOL
FOLIC ACID
CHEMBL1622135398658;5280354;6037OVBPIULPVIDEAO-LBPRGKRZSA-N
ExploreDB00205CP6
5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE
CHEMBL364993WKSAUQYGYAYLPV-UHFFFAOYSA-N
ExploreDB00440TOP
TRIMETHOPRIM
CHEMBL225578IEDVJHCEMCRBQM-UHFFFAOYSA-N
ExploreDB00563MTX
METHOTREXATE
CHEMBL34259126941FBOZXECLQNJBKD-ZDUSSCGKSA-N
ExploreDB00642LYA
2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID
CHEMBL225072135410875;446556;5288715WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
ExploreDB00798n/a
Gentamicin
n/an/an/a
ExploreDB00898EOH
ETHANOL
CHEMBL545702LFQSCWFLJHTTHZ-UHFFFAOYSA-N
ExploreDB01093DMS
DIMETHYL SULFOXIDE
CHEMBL504679IAZDPXIOMUYVGZ-UHFFFAOYSA-N
ExploreDB01131XEW
N-(4-chlorophenyl)-N'-(propan-2-yl)triimidodicarbonic diamide
CHEMBL13774923;5353897;5361395;6178111;6328384SSOLNOMRVKKSON-UHFFFAOYSA-N
ExploreDB01157TMQ
TRIMETREXATE
None5582;59961053NOYPYLRCIDNJJB-UHFFFAOYSA-O
ExploreDB02026MOT
N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE
CHEMBL104829158376WXINNGCGSCFUCR-ZDUSSCGKSA-N
ExploreDB02104CO4
2,4-DIAMINO-5-METHYL-6-[(3,4,5-TRIMETHOXY-N-METHYLANILINO)METHYL]PYRIDO[2,3-D]PYRIMIDINE
CHEMBL50514447815PEGMMEYCSOZKIT-UHFFFAOYSA-N
ExploreDB02338NDP
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
CHEMBL407009134821689;5884ACFIXJIJDZMPPO-NNYOXOHSSA-N
ExploreDB02427COG
2,4-DIAMINO-6-[N-(2',5'-DIMETHOXYBENZYL)-N-METHYLAMINO]QUINAZOLINE
CHEMBL325434447021YBJANOUTWRTBDK-UHFFFAOYSA-N
ExploreDB02559TQT
6-(OCTAHYDRO-1H-INDOL-1-YLMETHYL)DECAHYDROQUINAZOLINE-2,4-DIAMINE
None17754203HDQIGGQUKAQTGU-SZTTVXCBSA-N
ExploreDB02583PRD
N6-(2,5-DIMETHOXY-BENZYL)-N6-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4,6-TRIAMINE
CHEMBL32113444617HZTFNSCZLJLPEO-UHFFFAOYSA-N
ExploreDB02919DTM
2,4-DIAMINO-6-[N-(3',4',5'-TRIMETHOXYBENZYL)-N-METHYLAMINO]PYRIDO[2,3-D]PYRIMIDINE
CHEMBL32190447229PUOZHLHNKHRTOW-UHFFFAOYSA-N
ExploreDB03060LII
(Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE
None446753WNDJHUNKXPAREB-PLNGDYQASA-N
ExploreDB03125TRR
2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM
None3382784;446998IEDVJHCEMCRBQM-UHFFFAOYSA-O
ExploreDB03351LIH
6-([5-QUINOLYLAMINO]METHYL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE
CHEMBL151958446752KMSATRJZEXNGDP-UHFFFAOYSA-N
ExploreDB03461NAP
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
CHEMBL29506957525501;5885XJLXINKUBYWONI-NNYOXOHSSA-N
ExploreDB03695MXA
6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE
CHEMBL749254369VJXSSYDSOJBUAV-UHFFFAOYSA-N
ExploreDB03886BIO
BIOPTERIN
None135449517;444475;5287790LHQIJBMDNUYRAM-AWFVSMACSA-N
ExploreDB03987COQ
2,4-DIAMINO-6-[N-(3',5'-DIMETHOXYBENZYL)-N-METHYLAMINO]PYRIDO[2,3-D]PYRIMIDINE
CHEMBL36245447022XWCCXDBXMCTZPW-UHFFFAOYSA-N
ExploreDB0432221V
N-(4-{2-[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}benzoyl)-L-glutamic acid
None135409836;445072;5288680ZUQBAQVRAURMCL-WFASDCNBSA-N
ExploreDB04322L24
[[[2-AMINO-5,6,7,8-TETRAHYDRO-4-HYDROXY-PYRIDO[2,3-D]PYRIMIDIN-6-YL]-ETHYL]-PHENYL]-CARBONYL-GLUTAMIC ACID
None135409836;445072;5288680ZUQBAQVRAURMCL-WFASDCNBSA-N
ExploreDB04447DTT
2,3-DIHYDROXY-1,4-DITHIOBUTANE
CHEMBL406270439196VHJLVAABSRFDPM-IMJSIDKUSA-N
ExploreDB06178COP
N-(4-CARBOXY-4-{4-[(2,4-DIAMINO-PTERIDIN-6-YLMETHYL)-AMINO]-BENZOYLAMINO}-BUTYL)-PHTHALAMIC ACID
CHEMBL590985130731NYQPLPNEESYGNO-IBGZPJMESA-N
ExploreDB06358n/a
Iclaprim
n/an/an/a
ExploreDB06813n/a
Pralatrexate
n/an/an/a
ExploreDB0714053R
5-[(3R)-3-(5-methoxybiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
CHEMBL45917725093369JPENSYBRTSIYGO-AWEZNQCLSA-N
ExploreDB0714153S
5-[(3R)-3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
CHEMBL57521844144378QVXYJVHNRPNRJL-HNNXBMFYSA-N
ExploreDB0714253T
5-[(3R)-3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
CHEMBL57696044144379ATFDKOLABYIYCC-INIZCTEOSA-N
ExploreDB0714453V
5-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine
CHEMBL57307744144380XZXVRKHUCSXVBM-AWEZNQCLSA-N
ExploreDB08234N22
5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine
CHEMBL48596125058133NNFDQABYXZBKRK-UHFFFAOYSA-N
ExploreDB08406PMD
[N-(2,4-DIAMINOPTERIDIN-6-YL)-METHYL]-DIBENZ[B,F]AZEPINE
CHEMBL301769446744NXCCIJQEAKMFGW-UHFFFAOYSA-N
ExploreDB08448Q22
(4aS)-5-[(2,4-diaminopteridin-6-yl)methyl]-4a,5-dihydro-2H-dibenzo[b,f]azepin-8-ol
None46937152PCBWLKUEKANDCL-INIZCTEOSA-N
ExploreDB08642TQD
(2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine
None46937168JJWPLCQODKLEHY-JEOXALJRSA-N
ExploreDB09462GOL
GLYCEROL
CHEMBL692753PEDCQBHIVMGVHV-UHFFFAOYSA-N
ExploreDB14523PO4
PHOSPHATE ION
None1061NBIIXXVUZAFLBC-UHFFFAOYSA-K
ExploreDB14546SO4
SULFATE ION
None1117QAOWNCQODCNURD-UHFFFAOYSA-L
ExploreNone06U
6-ethyl-5-{(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine
CHEMBL448357256955942KEPLBUUTAQCZOE-AWEZNQCLSA-N
ExploreNone1QZ
6-ethyl-5-{(3S)-3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine
None71737835MGLLCDAARSVGLO-MRXNPFEDSA-N
ExploreNone1R0
6-ethyl-5-{3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine
CHEMBL233542071560296IZQBFFXMDOOSIE-UHFFFAOYSA-N
ExploreNone25U
6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine
CHEMBL364452371737834UEZKDWYIIOOENX-UHFFFAOYSA-N
ExploreNone34B
2,4-DIAMINO-5-(1-O-CARBORANYLMETHYL)-6-METHYLPYRIMIDINE
Nonen/aKWXMVDFGVQUJHY-UHFFFAOYSA-N
ExploreNone39B
(S)-2,4-DIAMINO-5-((7,8-DICARBAUNDECABORAN-7-YL)METHYL)-6-METHYLPYRIMIDINE
Nonen/aLMKIHIJGTSLZFQ-UHFFFAOYSA-N
ExploreNone3TU
(2S)-2-(5-{[(2-amino-4-oxo-3,4-dihydro[1]benzothieno[2,3-d]pyrimidin-5-yl)methyl]amino}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)pentanedioic acid
CHEMBL173874052914861QPDXRVRRCIFNSL-HNNXBMFYSA-N
ExploreNone3TZ
N-[(4-{[(2-amino-4-oxo-3,4-dihydro[1]benzothieno[2,3-d]pyrimidin-5-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
CHEMBL173874152914860GLRZVZIDWYADTN-AWEZNQCLSA-N
ExploreNone4RI
6-hexyl-5-phenyl-pyrimidine-2,4-diamine
CHEMBL4165529881905DBCDYKFZHWOABJ-UHFFFAOYSA-N
ExploreNone51P
5-[(1Z)-2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine
CHEMBL60603911687971JXICVPBZQSPDOK-CLFYSBASSA-N
ExploreNone63W
5-methyl-6-{[4-(trifluoromethyl)phenyl]sulfanyl}thieno[2,3-d]pyrimidine-2,4-diamine
None124037101VWQMUQCLRMRITR-UHFFFAOYSA-N
ExploreNone63Y
5-methyl-6-[(2,3,4-trifluorophenyl)sulfanyl]thieno[2,3-d]pyrimidine-2,4-diamine
None124037103HOYROOKWEBIDCA-UHFFFAOYSA-N
ExploreNone64J
5-methyl-6-{[4-(trifluoromethoxy)phenyl]sulfanyl}thieno[2,3-d]pyrimidine-2,4-diamine
None124037104HDFJEMJYJKUGRK-UHFFFAOYSA-N
ExploreNone65H
6-[(4-methoxyphenyl)sulfanyl]-5,7-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
CHEMBL4226465124080838OKWZEJPRXOZLRD-UHFFFAOYSA-N
ExploreNone65J
7-ethyl-6-[(3-methoxyphenyl)sulfanyl]-5-methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
CHEMBL4227124124080837ULDSMDKWSKBCEI-UHFFFAOYSA-N
ExploreNone65N
N~6~-methyl-N~6~-[4-(trifluoromethoxy)phenyl]pyrido[3,2-d]pyrimidine-2,4,6-triamine
None124080840JEGBSKQTMYWCPV-UHFFFAOYSA-N
ExploreNone65O
5-methyl-6-(naphthalen-1-ylsulfanyl)thieno[2,3-d]pyrimidine-2,4-diamine
None124080841DSWPJTXRDPNDRO-UHFFFAOYSA-N
ExploreNone65Q
5-methyl-6-{[3-(trifluoromethoxy)phenyl]sulfanyl}thieno[2,3-d]pyrimidine-2,4-diamine
None137348431DAABFILHHVUIKM-UHFFFAOYSA-N
ExploreNone684
4-({5-[(2,4-diaminopteridin-6-yl)methyl]-5H-dibenzo[b,f]azepin-2-yl}oxy)butanoic acid
CHEMBL43082111442756ORMJWSHZQMNLEH-UHFFFAOYSA-N
ExploreNone9DR
6-ethyl-5-{3-[3-methoxy-5-(pyridin-4-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine
CHEMBL321980457149550COHGVYNMDPBQFR-UHFFFAOYSA-N
ExploreNone9QO
5-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine
CHEMBL444273550992060IMDBCJZTZFNOKU-UHFFFAOYSA-N
ExploreNone9QR
5-(4-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine
CHEMBL446272660199138VSAKYGGFYNIPDW-UHFFFAOYSA-N
ExploreNoneCA
CALCIUM ION
None271BHPQYMZQTOCNFJ-UHFFFAOYSA-N
ExploreNoneCD
CADMIUM ION
None31193WLZRMCYVCSSEQC-UHFFFAOYSA-N
ExploreNoneCL
CHLORIDE ION
None312VEXZGXHMUGYJMC-UHFFFAOYSA-M
ExploreNoneD2B
5-[(1Z)-2-(2-methoxyphenyl)-3-methylbut-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine
None44246320ZBHMLBFDTQKTKI-JYRVWZFOSA-N
ExploreNoneD2D
5-[(1E)-2-(2-methoxyphenyl)-4-methylpent-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine
None49795046GSEWOBPWXZKJLQ-FMIVXFBMSA-N
ExploreNoneD2E
5-[(E)-2-cyclopropyl-2-(2-methoxyphenyl)ethenyl]furo[2,3-d]pyrimidine-2,4-diamine
None49866880PUOLMVSSUQSKAQ-MDWZMJQESA-N
ExploreNoneD2F
5-[(1E)-2-(2-methoxyphenyl)hex-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine
None49866881OJEFVGFDNJBOHB-ZRDIBKRKSA-N
ExploreNoneD2H
5-[(1E,3R)-2-(2-methoxyphenyl)-3-methylpent-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine
None49866882GGNUJBNONVTLHE-ZECSTPGPSA-N
ExploreNoneD2Q
ethyl 5-{2-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy}pentanoate
None49866884BHQORMWWDFDSIW-UHFFFAOYSA-N
ExploreNoneDH1
2,4-DIAMINO-5-[2-METHOXY-5-(4-CARBOXYBUTYLOXY)BENZYL]PYRIMIDINE
CHEMBL37520490573ALDCXILJAYAUTH-UHFFFAOYSA-N
ExploreNoneDZF
5-DEAZAFOLIC ACID
None135460994;445175NFARHPAOOHOWAL-AWEZNQCLSA-N
ExploreNoneEDO
1,2-ETHANEDIOL
CHEMBL457299174LYCAIKOWRPUZTN-UHFFFAOYSA-N
ExploreNoneG3V
N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic acid
None137349387KWWKVKGHDTULAH-ZDUSSCGKSA-N
ExploreNoneG6Y
3'-[(2R)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid
CHEMBL3828485124081251OKJCHFXBCVXSIZ-AWEZNQCLSA-N
ExploreNoneGI6
(2R)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanamide
Nonen/aYFNRZOCVPAVTJW-GFCCVEGCSA-N
ExploreNoneHJI
(2R)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid
None162540405UXIGBQRLXSDLOT-LBPRGKRZSA-N
ExploreNoneHXV
6-ethyl-5-(4-{2-[2-(1H-tetrazol-5-yl)ethyl]phenoxy}butoxy)pyrimidine-2,4-diamine
None162540413OUJSJGDTRMGLDA-UHFFFAOYSA-N
ExploreNoneHZU
(2S)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3-fluoropropanoic acid
Nonen/aCDIUQIVTNPRVDS-CYBMUJFWSA-N
ExploreNoneI0E
(2S)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanoic acid
None162540399ZLMWHEULHKTIRM-LBPRGKRZSA-N
ExploreNoneI6J
(2S)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid
None162540409UXIGBQRLXSDLOT-GFCCVEGCSA-N
ExploreNoneIXE
N~6~-methyl-N~6~-(3,4,5-trifluorophenyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine
CHEMBL238233671463580RYXUPKGYPPPMSC-UHFFFAOYSA-N
ExploreNoneIXF
N~6~-methyl-N~6~-[4-(propan-2-yl)phenyl]pyrido[2,3-d]pyrimidine-2,4,6-triamine
CHEMBL238233271463581CRSDIJKYSOUKQH-UHFFFAOYSA-N
ExploreNoneK
POTASSIUM ION
CHEMBL1233793813NPYPAHLBTDXSSS-UHFFFAOYSA-N
ExploreNoneLG3
PYRIMIDINE-2,4-DIAMINE
CHEMBL123398767431YAAWASYJIRZXSZ-UHFFFAOYSA-N
ExploreNoneMG
MAGNESIUM ION
None888JLVVSXFLKOJNIY-UHFFFAOYSA-N
ExploreNoneMMV
3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid
CHEMBL304003866563688VDGXZSSDCDPCRF-UHFFFAOYSA-N
ExploreNoneNH4
AMMONIUM ION
None16741146;223QGZKDVFQNNGYKY-UHFFFAOYSA-O
ExploreNoneNPX
(2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid
CHEMBL1618254169118CMWTZPSULFXXJA-SECBINFHSA-N
ExploreNoneOAG
6-{[(2,5-dichlorophenyl)amino]methyl}pyrido[2,3-d]pyrimidine-2,4-diamine
CHEMBL145979472910RSPDQFOJWPXTPN-UHFFFAOYSA-N
ExploreNoneSR
STRONTIUM ION
None104798PWYYWQHXAPXYMF-UHFFFAOYSA-N
ExploreNoneVG9
6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE
CHEMBL279679457349KKMWDWUZXFYKLD-UHFFFAOYSA-N