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TRIMETREXATE

P00374 — Dihydrofolate reductase

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Attributes

UniProt ID
P00374
Protein Name
Dihydrofolate reductase
Ligand Name
TRIMETREXATE
DrugBank ID
DB01157
PDB Ligand Accession
TMQ
ChEMBL ID
None
PubChem ID
5582; 59961053
InChIKey
NOYPYLRCIDNJJB-UHFFFAOYSA-O
SMILES
Cc1c(ccc2c1c(nc([nH+]2)N)N)CNc3cc(c(c(c3)OC)OC)OC
Drug Action
inhibitor
Affinity Metrics
ki:0.04 nM
ic50:0.42 nM