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6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE

P00374 — Dihydrofolate reductase

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Attributes

UniProt ID
P00374
Protein Name
Dihydrofolate reductase
Ligand Name
6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE
DrugBank ID
DB03695
PDB Ligand Accession
MXA
ChEMBL ID
CHEMBL7492
PubChem ID
54369
InChIKey
VJXSSYDSOJBUAV-UHFFFAOYSA-N
SMILES
Cc1c(cnc2c1c(nc(n2)N)N)Cc3cc(ccc3OC)OC
Drug Action
modulator
Affinity Metrics
ki:0.025 nM
ic50:0.61 nM