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METHOTREXATE

P00374 — Dihydrofolate reductase

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Attributes

UniProt ID
P00374
Protein Name
Dihydrofolate reductase
Ligand Name
METHOTREXATE
DrugBank ID
DB00563
PDB Ligand Accession
MTX
ChEMBL ID
CHEMBL34259
PubChem ID
126941
InChIKey
FBOZXECLQNJBKD-ZDUSSCGKSA-N
SMILES
CN(Cc1cnc2c(n1)c(nc(n2)N)N)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O
Drug Action
inhibitor
Affinity Metrics
ki:0.00034 nM
ic50:0.7 nM
kd:0.194984 nM
ec50:12.5 nM