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Attributes

UniProt ID
P00374
Protein Name
Dihydrofolate reductase
Ligand Name
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
DrugBank ID
DB03461
PDB Ligand Accession
NAP
ChEMBL ID
n/a
PubChem ID
n/a
InChIKey
XJLXINKUBYWONI-NNYOXOHSSA-N
SMILES
c1cc(c[n+](c1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)n4cnc5c4ncnc5N)OP(=O)(O)O)O)O)O)C(=O)N
Drug Action
No data available
Affinity Metrics
No affinity data available

3D Structure

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Mol*
Structure: 1S3W
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Color Legend
Unassigned regionsLigand / hetero atomse1s3wA1
ECOD domains from experimental PDB structures interacting with ligand DB03461
UniProtDrugBankPDB LigandPDB IDECOD DomainRange Definition
P00374DB03461NAP1s3we1s3wA1A:1-186
P00374DB03461NAP4m6ke4m6kA1A:1-186
P00374DB03461NAP4m6le4m6lA1A:1-186
P00374DB03461NAP5sd6e5sd6A1A:1-187
P00374DB03461NAP5sd7e5sd7A1A:2-187
P00374DB03461NAP5sd8e5sd8A1A:2-187
P00374DB03461NAP5sd9e5sd9A1A:2-187
P00374DB03461NAP5sdae5sdaA1A:2-187
P00374DB03461NAP5sdbe5sdbA1A:2-187
P00374DB03461NAP5sdbe5sdbB1B:2-187
P00374DB03461NAP6dave6davA1A:2-187
P00374DB03461NAP6dave6davB1B:2-187
P00374DB03461NAP6vcje6vcjA1A:3-186
P00374DB03461NAP6vcje6vcjB1B:2-185
P00374DB03461NAP6vcje6vcjC1C:2-186
P00374DB03461NAP6vcje6vcjD1D:2-186
P00374DB03461NAP7esee7eseA1A:3-187