DrugDomain logoDrugDomain

N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide

P00533 — Epidermal growth factor receptor

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Attributes

UniProt ID
P00533
Protein Name
Epidermal growth factor receptor
Ligand Name
N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide
DrugBank ID
DB09330
PDB Ligand Accession
YY3
ChEMBL ID
CHEMBL3353410
PubChem ID
71496458
InChIKey
DUYJMQONPNNFPI-UHFFFAOYSA-N
SMILES
Cn1cc(c2c1cccc2)c3ccnc(n3)Nc4cc(c(cc4OC)N(C)CCN(C)C)NC(=O)C=C
Drug Action
inhibitor
Affinity Metrics
ki:3.5 nM
ic50:0.002 nM
ec50:6 nM