DrugDomain logoDrugDomain

(2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide

P04626 — Receptor tyrosine-protein kinase erbB-2

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Attributes

UniProt ID
P04626
Protein Name
Receptor tyrosine-protein kinase erbB-2
Ligand Name
(2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
DrugBank ID
DB08916
PDB Ligand Accession
0WM
ChEMBL ID
CHEMBL1173655
PubChem ID
10184653
InChIKey
ULXXDDBFHOBEHA-CWDCEQMOSA-N
SMILES
CN(C)CC=CC(=O)Nc1cc2c(cc1OC3CCOC3)ncnc2Nc4ccc(c(c4)Cl)F
Drug Action
inhibitor
Affinity Metrics
ic50:0.57 nM
kd:5 nM
ec50:3 nM