(2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide

P04626 — Receptor tyrosine-protein kinase erbB-2

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand DB08916

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
P04626	DB08916	0WM	nD1	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	Recep_L_domain
P04626	DB08916	0WM	nD2	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	Furin-like
P04626	DB08916	0WM	nD3	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	Recep_L_domain
P04626	DB08916	0WM	nD4	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	GF_recep_IV
P04626	DB08916	0WM	nD6	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	PK_Tyr_Ser-Thr

Show other predicted domains (80)

PDB ID	Domain Name	ECOD ID	X Group	H Group	T Group	F Group
1N8Z	e1n8zC1	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e1n8zC2	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e1n8zC3	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e1n8zC4	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
1S78	e1s78A1	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e1s78A2	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e1s78B5	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e1s78B7	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e1s78A3	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e1s78A4	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e1s78B6	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e1s78B8	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
2A91	e2a91A1	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e2a91A2	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e2a91A3	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
2N2A	e2n2aA1	3569.1.1	Epidermal growth factor receptor transmembrane-juxtamembrane segment-like	Epidermal growth factor receptor transmembrane-juxtamembrane segment	Epidermal growth factor receptor transmembrane-juxtamembrane segment	TM_ErbB1
2N2A	e2n2aB1	3569.1.1	Epidermal growth factor receptor transmembrane-juxtamembrane segment-like	Epidermal growth factor receptor transmembrane-juxtamembrane segment	Epidermal growth factor receptor transmembrane-juxtamembrane segment	TM_ErbB1
3BE1	e3be1A5	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e3be1A7	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e3be1A6	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e3be1A8	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
3H3B	e3h3bA1	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
3H3B	e3h3bB1	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
3MZW	e3mzwA9	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e3mzwA11	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e3mzwA10	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e3mzwA12	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
3N85	e3n85A1	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e3n85A2	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e3n85A3	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e3n85A4	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
3PP0	e3pp0A1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
3PP0	e3pp0B1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
3RCD	e3rcdB1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e3rcdD1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e3rcdA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
	e3rcdC1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
3WLW	e3wlwA1	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e3wlwA2	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e3wlwB3	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e3wlwB4	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e3wlwA3	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e3wlwA4	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e3wlwB1	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e3wlwB2	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
3WSQ	e3wsqA1	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e3wsqA4	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e3wsqA2	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e3wsqA3	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
4HRL	e4hrlC2	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
4HRM	e4hrmC1	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
4HRM	e4hrmA1	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
4HRN	e4hrnC1	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
4HRN	e4hrnD1	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
5K33	e5k33C1	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e5k33C4	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e5k33C2	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e5k33C3	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
5KWG	e5kwgC3	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e5kwgC4	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e5kwgC1	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e5kwgC2	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
5MY6	e5my6A1	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e5my6A4	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e5my6A2	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e5my6A3	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
5O4G	e5o4gC2	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e5o4gC3	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e5o4gC1	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e5o4gC4	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
5OB4	e5ob4A1	3569.1.1	Epidermal growth factor receptor transmembrane-juxtamembrane segment-like	Epidermal growth factor receptor transmembrane-juxtamembrane segment	Epidermal growth factor receptor transmembrane-juxtamembrane segment	TM_ErbB1
5OB4	e5ob4B1	3569.1.1	Epidermal growth factor receptor transmembrane-juxtamembrane segment-like	Epidermal growth factor receptor transmembrane-juxtamembrane segment	Epidermal growth factor receptor transmembrane-juxtamembrane segment	TM_ErbB1
6ATT	e6attA3	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e6attA4	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e6attA1	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e6attA2	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
6BGT	e6bgtC3	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e6bgtC4	207.1.1	Single-stranded right-handed beta-helix	Leucine-rich repeats	Leucine-rich repeats	LRR_1
	e6bgtC1	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP
	e6bgtC2	389.6.1	EGF-like	Growth factor receptor domain	Growth factor receptor domain	IGFBP

ECOD domains from experimental PDB structures interacting with ligand DB08916

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
No experimental ECOD data found