DrugDomain logoDrugDomain

4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile

P08631 — Tyrosine-protein kinase HCK

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand DB06616

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
P08631DB06616DB8nD3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePK_Tyr_Ser-Thr
Show other predicted domains (149)
PDB IDDomain NameECOD IDX GroupH GroupT GroupF Group
1AD5e1ad5B3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e1ad5A3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e1ad5A2214.1.1SH2SH2SH2SH2
e1ad5B2214.1.1SH2SH2SH2SH2
e1ad5B14.1.1SH3SH3SH3SH3_1
e1ad5A14.1.1SH3SH3SH3SH3_1
1BU1e1bu1B14.1.1SH3SH3SH3SH3_1
e1bu1C14.1.1SH3SH3SH3SH3_1
e1bu1E14.1.1SH3SH3SH3SH3_1
e1bu1F14.1.1SH3SH3SH3SH3_1
e1bu1A14.1.1SH3SH3SH3SH3_1
e1bu1D14.1.1SH3SH3SH3SH3_1
1QCFe1qcfA3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e1qcfA2214.1.1SH2SH2SH2SH2
e1qcfA14.1.1SH3SH3SH3SH3_1
2C0Ie2c0iA3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e2c0iB3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e2c0iA2214.1.1SH2SH2SH2SH2
e2c0iB2214.1.1SH2SH2SH2SH2
e2c0iA14.1.1SH3SH3SH3SH3_1
e2c0iB14.1.1SH3SH3SH3SH3_1
2C0Oe2c0oA3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e2c0oB3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e2c0oA2214.1.1SH2SH2SH2SH2
e2c0oB2214.1.1SH2SH2SH2SH2
e2c0oA14.1.1SH3SH3SH3SH3_1
e2c0oB14.1.1SH3SH3SH3SH3_1
2C0Te2c0tA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e2c0tB3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e2c0tA2214.1.1SH2SH2SH2SH2
e2c0tB2214.1.1SH2SH2SH2SH2
e2c0tA34.1.1SH3SH3SH3SH3_1
e2c0tB14.1.1SH3SH3SH3SH3_1
2HCKe2hckB3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e2hckA3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e2hckA2214.1.1SH2SH2SH2SH2
e2hckB2214.1.1SH2SH2SH2SH2
e2hckA14.1.1SH3SH3SH3SH3_1
e2hckB14.1.1SH3SH3SH3SH3_1
2HK5e2hk5A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
2OI3e2oi3A24.1.1SH3SH3SH3SH3_1
2OJ2e2oj2A24.1.1SH3SH3SH3SH3_1
3HCKe3hckA1214.1.1SH2SH2SH2SH2
3NHNe3nhnA2214.1.1SH2SH2SH2SH2
e3nhnA14.1.1SH3SH3SH3SH3_1
3RBBe3rbbB14.1.1SH3SH3SH3SH3_1
e3rbbD14.1.1SH3SH3SH3SH3_1
3REAe3reaB14.1.1SH3SH3SH3SH3_1
e3reaD14.1.1SH3SH3SH3SH3_1
3REBe3rebB14.1.1SH3SH3SH3SH3_1
e3rebD14.1.1SH3SH3SH3SH3_1
3VRYe3vryB3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vryA3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vryB2214.1.1SH2SH2SH2SH2
e3vryA2214.1.1SH2SH2SH2SH2
e3vryB14.1.1SH3SH3SH3SH3_1
e3vryA14.1.1SH3SH3SH3SH3_1
3VRZe3vrzA3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vrzB3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vrzA2214.1.1SH2SH2SH2SH2
e3vrzB2214.1.1SH2SH2SH2SH2
e3vrzA14.1.1SH3SH3SH3SH3_1
e3vrzB14.1.1SH3SH3SH3SH3_1
3VS0e3vs0A3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs0B3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs0A2214.1.1SH2SH2SH2SH2
e3vs0B2214.1.1SH2SH2SH2SH2
e3vs0A14.1.1SH3SH3SH3SH3_1
e3vs0B14.1.1SH3SH3SH3SH3_1
3VS1e3vs1B3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs1A4206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs1B2214.1.1SH2SH2SH2SH2
e3vs1A5214.1.1SH2SH2SH2SH2
e3vs1B14.1.1SH3SH3SH3SH3_1
e3vs1A64.1.1SH3SH3SH3SH3_1
3VS2e3vs2B3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs2A3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs2B2214.1.1SH2SH2SH2SH2
e3vs2A2214.1.1SH2SH2SH2SH2
e3vs2B14.1.1SH3SH3SH3SH3_1
e3vs2A14.1.1SH3SH3SH3SH3_1
3VS3e3vs3B3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs3A3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs3B2214.1.1SH2SH2SH2SH2
e3vs3A2214.1.1SH2SH2SH2SH2
e3vs3B14.1.1SH3SH3SH3SH3_1
e3vs3A14.1.1SH3SH3SH3SH3_1
3VS4e3vs4A3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs4B3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs4A2214.1.1SH2SH2SH2SH2
e3vs4B2214.1.1SH2SH2SH2SH2
e3vs4A14.1.1SH3SH3SH3SH3_1
e3vs4B14.1.1SH3SH3SH3SH3_1
3VS5e3vs5B3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs5A3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs5B2214.1.1SH2SH2SH2SH2
e3vs5A2214.1.1SH2SH2SH2SH2
e3vs5B14.1.1SH3SH3SH3SH3_1
e3vs5A14.1.1SH3SH3SH3SH3_1
3VS6e3vs6A3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs6B3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs6A2214.1.1SH2SH2SH2SH2
e3vs6B2214.1.1SH2SH2SH2SH2
e3vs6A14.1.1SH3SH3SH3SH3_1
e3vs6B14.1.1SH3SH3SH3SH3_1
3VS7e3vs7B3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs7A3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3vs7B2214.1.1SH2SH2SH2SH2
e3vs7A2214.1.1SH2SH2SH2SH2
e3vs7B14.1.1SH3SH3SH3SH3_1
e3vs7A14.1.1SH3SH3SH3SH3_1
4HCKe4hckA14.1.1SH3SH3SH3SH3_1
4LUDe4ludA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e4ludB1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e4ludA2214.1.1SH2SH2SH2SH2
e4ludB4214.1.1SH2SH2SH2SH2
e4ludA34.1.1SH3SH3SH3SH3_1
e4ludB54.1.1SH3SH3SH3SH3_1
4LUEe4lueA4206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e4lueB1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e4lueA5214.1.1SH2SH2SH2SH2
e4lueB2214.1.1SH2SH2SH2SH2
e4lueA34.1.1SH3SH3SH3SH3_1
e4lueB34.1.1SH3SH3SH3SH3_1
4ORZe4orzA14.1.1SH3SH3SH3SH3_1
4U5We4u5wB1214.1.1SH2SH2SH2SH2
e4u5wD1214.1.1SH2SH2SH2SH2
e4u5wB24.1.1SH3SH3SH3SH3_1
e4u5wD24.1.1SH3SH3SH3SH3_1
5H09e5h09A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5h09A3214.1.1SH2SH2SH2SH2
e5h09A24.1.1SH3SH3SH3SH3_1
5H0Be5h0bA3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5h0bA1214.1.1SH2SH2SH2SH2
e5h0bA24.1.1SH3SH3SH3SH3_1
5H0Ee5h0eA3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5h0eA1214.1.1SH2SH2SH2SH2
e5h0eA24.1.1SH3SH3SH3SH3_1
5H0Ge5h0gA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5h0gA3214.1.1SH2SH2SH2SH2
e5h0gA24.1.1SH3SH3SH3SH3_1
5H0He5h0hA3206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5h0hA1214.1.1SH2SH2SH2SH2
e5h0hA24.1.1SH3SH3SH3SH3_1
5HCKe5hckA14.1.1SH3SH3SH3SH3_1
5NUHe5nuhC14.1.1SH3SH3SH3SH3_1
e5nuhD14.1.1SH3SH3SH3SH3_1
5ZJ6e5zj6A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5zj6B1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase

ECOD domains from experimental PDB structures interacting with ligand DB06616

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
No experimental ECOD data found