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(1S,2S)-2-[(N-{[(4,4-difluorocyclohexyl)methoxy]carbonyl}-L-leucyl)amino]-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid

P0C6U8 — Replicase polyprotein 1a

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand QYS

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand QYS

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
P0C6U8n/a6w2aQYSA402e6w2aA1Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainCoronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainCoronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainPeptidase_C30
P0C6U8n/a6w2aQYSA402e6w2aA2cradle loop barrelRIFT-relatedFMN-binding split barrelPeptidase_C30
P0C6U8n/a6w2aQYSB401e6w2aA1Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainCoronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainCoronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainPeptidase_C30
P0C6U8n/a6w2aQYSB401e6w2aA2cradle loop barrelRIFT-relatedFMN-binding split barrelPeptidase_C30
P0C6U8n/a6w2aQYSB401e6w2aB1cradle loop barrelRIFT-relatedFMN-binding split barrelPeptidase_C30
P0C6U8n/a6w2aQYSB401e6w2aB2Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainCoronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainCoronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainPeptidase_C30