(2~{S})-4-methyl-~{N}-[(2~{S},3~{R})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]-2-[[(~{E})-3-phenylprop-2-enoyl]amino]pentanamide

P0C6X5 — Replicase polyprotein 1ab

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand E8E

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand E8E

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
P0C6X5	n/a	6fv1	E8E	A	401	e6fv1A1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0C6X5	n/a	6fv1	E8E	A	401	e6fv1A2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0C6X5	n/a	6fv1	E8E	B	401	e6fv1A1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0C6X5	n/a	6fv1	E8E	B	401	e6fv1B1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0C6X5	n/a	6fv1	E8E	B	401	e6fv1B2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0C6X5	n/a	6fv1	E8E	B	401	e6fv1C1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0C6X5	n/a	6fv1	E8E	C	401	e6fv1B1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0C6X5	n/a	6fv1	E8E	C	401	e6fv1C1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0C6X5	n/a	6fv1	E8E	C	401	e6fv1C2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30