(1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide

P0DTC1 — Replicase polyprotein 1a

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand 4WI

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand 4WI

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
P0DTC1	n/a	7tll	4WI	A	401	e7tllA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7tll	4WI	A	401	e7tllA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7tll	4WI	A	401	e7tllB1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7tll	4WI	B	401	e7tllA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7tll	4WI	B	401	e7tllA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7tll	4WI	B	401	e7tllB1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7tll	4WI	B	401	e7tllB2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7u28	4WI	A	401	e7u28A1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7u28	4WI	A	401	e7u28A2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7u28	4WI	A	401	e7u28B1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7u28	4WI	B	401	e7u28A1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7u28	4WI	B	401	e7u28A2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7u28	4WI	B	401	e7u28B1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7u28	4WI	B	401	e7u28B2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7u29	4WI	A	401	e7u29A1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7u29	4WI	A	401	e7u29A2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7u29	4WI	A	401	e7u29B1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7u29	4WI	B	401	e7u29A1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7u29	4WI	B	401	e7u29A2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7u29	4WI	B	401	e7u29B1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7u29	4WI	B	401	e7u29B2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7uju	4WI	A	401	e7ujuA1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7uju	4WI	B	401	e7ujuB1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7vh8	4WI	A	401	e7vh8A1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7vh8	4WI	A	401	e7vh8A2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7vlp	4WI	A	401	e7vlpA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7vlp	4WI	A	401	e7vlpA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7vlp	4WI	B	401	e7vlpB1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7vlp	4WI	B	401	e7vlpB2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7vlq	4WI	A	401	e7vlqA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7vlq	4WI	A	401	e7vlqA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7vlq	4WI	B	401	e7vlqB1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7vlq	4WI	B	401	e7vlqB2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7xb4	4WI	A	401	e7xb4A1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	7xb4	4WI	A	401	e7xb4A2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7xb4	4WI	B	401	e7xb4B1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	7xb4	4WI	B	401	e7xb4B2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	8h4y	4WI	A	401	e8h4yA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	8h4y	4WI	A	401	e8h4yA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	8h51	4WI	A	401	e8h51A1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	8h51	4WI	A	401	e8h51A2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	8h57	4WI	A	401	e8h57A1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	8h57	4WI	A	401	e8h57A2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	8h5f	4WI	A	401	e8h5fA1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	8h5f	4WI	A	401	e8h5fA2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	8h5p	4WI	A	401	e8h5pA1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	8h5p	4WI	A	401	e8h5pA2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	8h6n	4WI	A	401	e8h6nA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	8h6n	4WI	A	401	e8h6nA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	8h7w	4WI	A	401	e8h7wA1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	8h7w	4WI	A	401	e8h7wA2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	8h82	4WI	A	401	e8h82A1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	8h82	4WI	A	401	e8h82A2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTC1	n/a	8igy	4WI	A	401	e8igyA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTC1	n/a	8igy	4WI	A	401	e8igyA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30