(1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide

P0DTD1 — Replicase polyprotein 1ab

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand 4WI

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand 4WI

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
P0DTD1	n/a	7rfs	4WI	A	401	e7rfsA1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7rfs	4WI	A	401	e7rfsA2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	7rfw	4WI	A	401	e7rfwA1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7rfw	4WI	A	401	e7rfwA2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	7si9	4WI	A	401	e7si9A1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7si9	4WI	A	401	e7si9A2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	7te0	4WI	A	401	e7te0A1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	7te0	4WI	A	401	e7te0A2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7uup	4WI	A	401	e7uupA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	7uup	4WI	A	401	e7uupA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dcz	4WI	A	401	e8dczA1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dcz	4WI	A	401	e8dczA2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dcz	4WI	A	401	e8dczB2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dcz	4WI	B	401	e8dczA1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dcz	4WI	B	401	e8dczA2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dcz	4WI	B	401	e8dczB1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dcz	4WI	B	401	e8dczB2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz2	4WI	A	401	e8dz2A1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz2	4WI	A	401	e8dz2A2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dz2	4WI	A	401	e8dz2B2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz2	4WI	B	401	e8dz2A1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz2	4WI	B	401	e8dz2A2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dz2	4WI	B	401	e8dz2B1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dz2	4WI	B	401	e8dz2B2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz6	4WI	A	401	e8dz6A1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dz6	4WI	A	401	e8dz6A2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz6	4WI	A	401	e8dz6B2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz6	4WI	B	401	e8dz6A1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dz6	4WI	B	401	e8dz6A2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz6	4WI	B	401	e8dz6B1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dz6	4WI	B	401	e8dz6B2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz9	4WI	A	401	e8dz9A1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dz9	4WI	A	401	e8dz9A2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz9	4WI	A	401	e8dz9B2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz9	4WI	B	401	e8dz9A1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dz9	4WI	B	401	e8dz9A2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz9	4WI	B	401	e8dz9B1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dz9	4WI	B	401	e8dz9B2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz9	4WI	C	401	e8dz9C1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dz9	4WI	C	401	e8dz9C2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz9	4WI	C	401	e8dz9D2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz9	4WI	D	401	e8dz9C2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dz9	4WI	D	401	e8dz9D1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dz9	4WI	D	401	e8dz9D2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dza	4WI	A	402	e8dzaA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dza	4WI	A	402	e8dzaA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dza	4WI	A	402	e8dzaB2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dza	4WI	B	401	e8dzaA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dza	4WI	B	401	e8dzaA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8dza	4WI	B	401	e8dzaB1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8dza	4WI	B	401	e8dzaB2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8e1y	4WI	A	401	e8e1yA1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8e1y	4WI	A	401	e8e1yA2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8e1y	4WI	A	401	e8e1yB1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8e1y	4WI	B	402	e8e1yA1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8e1y	4WI	B	402	e8e1yA2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8e1y	4WI	B	402	e8e1yB1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8e1y	4WI	B	402	e8e1yB2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8e25	4WI	A	401	e8e25A1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8e25	4WI	A	401	e8e25A2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8e25	4WI	A	401	e8e25B2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8e25	4WI	B	401	e8e25A1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8e25	4WI	B	401	e8e25A2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8e25	4WI	B	401	e8e25B1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8e25	4WI	B	401	e8e25B2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8e26	4WI	A	401	e8e26A1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8e26	4WI	A	401	e8e26A2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8e26	4WI	A	401	e8e26B2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8e26	4WI	B	401	e8e26A1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8e26	4WI	B	401	e8e26A2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8e26	4WI	B	401	e8e26B1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8e26	4WI	B	401	e8e26B2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8eyj	4WI	A	401	e8eyjA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	8eyj	4WI	A	401	e8eyjA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8eyj	4WI	A	401	e8eyjB1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8eyj	4WI	B	401	e8eyjB1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	8eyj	4WI	B	401	e8eyjB2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30