(1'M,4S)-6-chloro-1'-(isoquinolin-4-yl)-2,3-dihydrospiro[[1]benzopyran-4,4'-imidazolidine]-2',5'-dione

P0DTD1 — Replicase polyprotein 1ab

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand P4R

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand P4R

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
P0DTD1	n/a	7ggp	P4R	A	404	e7ggpA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	7ggp	P4R	A	404	e7ggpA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7ghu	P4R	A	404	e7ghuA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	7ghu	P4R	A	404	e7ghuA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7ghu	P4R	A	404	e7ghuB2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7ghu	P4R	B	403	e7ghuA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7ghu	P4R	B	403	e7ghuB1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	7ghu	P4R	B	403	e7ghuB2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7gix	P4R	A	404	e7gixA1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7gix	P4R	A	404	e7gixA2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	7gix	P4R	A	404	e7gixB1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7gix	P4R	B	403	e7gixA1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7gix	P4R	B	403	e7gixB1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7gix	P4R	B	403	e7gixB2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30