(4S)-6-chloro-N-(isoquinolin-4-yl)-2-[2-(methylamino)-2-oxoethyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide

P0DTD1 — Replicase polyprotein 1ab

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand R76

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand R76

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
P0DTD1	n/a	7glb	R76	A	407	e7glbA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	7glb	R76	A	407	e7glbA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7glb	R76	A	407	e7glbB2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7glb	R76	B	403	e7glbA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7glb	R76	B	403	e7glbB1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	7glb	R76	B	403	e7glbB2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7glv	R76	A	408	e7glvA1	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30
P0DTD1	n/a	7glv	R76	A	408	e7glvA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7glv	R76	A	408	e7glvB1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7glv	R76	B	405	e7glvA2	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7glv	R76	B	405	e7glvB1	cradle loop barrel	RIFT-related	FMN-binding split barrel	Peptidase_C30
P0DTD1	n/a	7glv	R76	B	405	e7glvB2	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain	Peptidase_C30