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(4S)-6-chloro-2-{2-[4-(4-ethylpiperazin-1-yl)anilino]-2-oxoethyl}-N-(isoquinolin-4-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide

P0DTD1 — Replicase polyprotein 1ab

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand S1U

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand S1U

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
P0DTD1n/a7gnlS1UA407e7gnlA1Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainCoronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainCoronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainPeptidase_C30
P0DTD1n/a7gnlS1UA407e7gnlA2cradle loop barrelRIFT-relatedFMN-binding split barrelPeptidase_C30
P0DTD1n/a7gnlS1UA407e7gnlB1cradle loop barrelRIFT-relatedFMN-binding split barrelPeptidase_C30
P0DTD1n/a7gnlS1UB404e7gnlA1Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainCoronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainCoronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainPeptidase_C30
P0DTD1n/a7gnlS1UB404e7gnlA2cradle loop barrelRIFT-relatedFMN-binding split barrelPeptidase_C30
P0DTD1n/a7gnlS1UB404e7gnlB1cradle loop barrelRIFT-relatedFMN-binding split barrelPeptidase_C30
P0DTD1n/a7gnlS1UB404e7gnlB2Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainCoronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainCoronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainPeptidase_C30