~{N}-(4-hydroxyphenyl)-3-[6-[[(3~{S})-3-(morpholin-4-ylmethyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]-1,3-benzodioxol-5-yl]-~{N}-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide
P10415 — Apoptosis regulator Bcl-2
ECOD Domain Annotations
ECOD domains from AlphaFold model interacting with ligand DB18365
| UniProt | DrugBank | PDB Ligand | Domain Label | ECOD ID | X Group | H Group | T Group | F Group |
|---|---|---|---|---|---|---|---|---|
| No predicted ECOD data found | ||||||||
ECOD domains from experimental PDB structures interacting with ligand DB18365
| UniProt | DrugBank | PDB ID | Ligand Acc. | Chain | Res No. | Exp. Domain | X Group | H Group | T Group | F Group |
|---|---|---|---|---|---|---|---|---|---|---|
| P10415 | DB18365 | 6gl8 | F3Q | A | 301 | e6gl8A1 | Toxins' membrane translocation domains | Bcl-2 inhibitors of programmed cell death | Bcl-2 inhibitors of programmed cell death | Bcl-2,BH4 |
| P10415 | DB18365 | 6o0o | F3Q | A | 201 | e6o0oA1 | Toxins' membrane translocation domains | Bcl-2 inhibitors of programmed cell death | Bcl-2 inhibitors of programmed cell death | Bcl-2,BH4 |
| P10415 | DB18365 | 6o0o | F3Q | C | 201 | e6o0oC1 | Toxins' membrane translocation domains | Bcl-2 inhibitors of programmed cell death | Bcl-2 inhibitors of programmed cell death | Bcl-2,BH4 |