DrugDomain logoDrugDomain

4-ETHYL-4-HYDROXY-1,12-DIHYDRO-4H-2-OXA-6,12A-DIAZA-DIBENZO[B,H]FLUORENE-3,13-DIONE

P11387 — DNA topoisomerase 1

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Attributes

UniProt ID
P11387
Protein Name
DNA topoisomerase 1
Ligand Name
4-ETHYL-4-HYDROXY-1,12-DIHYDRO-4H-2-OXA-6,12A-DIAZA-DIBENZO[B,H]FLUORENE-3,13-DIONE
DrugBank ID
DB04690
PDB Ligand Accession
EHD
ChEMBL ID
CHEMBL65
PubChem ID
24360
InChIKey
VSJKWCGYPAHWDS-FQEVSTJZSA-N
SMILES
CCC1(C2=C(COC1=O)C(=O)N3Cc4cc5ccccc5nc4C3=C2)O
Drug Action
inhibitor
Affinity Metrics
ic50:25 nM
ec50:350 nM