DrugDomain logoDrugDomain

4'-chloro-3'-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl][1,1'-biphenyl]-4-carboxamide

P11731 — Dihydrofolate reductase type 5

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand 4SI

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand 4SI

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
P11731n/a7rgo4SIA203e7rgoA1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
P11731n/a7rgo4SIB204e7rgoB1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1