DrugDomain logoDrugDomain

methyl [(2S)-2-(5-{5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}-2-fluorophenyl)-3-(quinolin-3-yl)propyl]carbamate

P14735 — Insulin-degrading enzyme

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand 2QX

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand 2QX

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
P14735n/a4pfc2QXA1101e4pfcA1LuxS, MPP, ThrRS/AlaRS common domainLuxS, MPP, ThrRS/AlaRS common domainLuxS/MPP-like metallohydrolasePeptidase_M16,Peptidase_M16_C
P14735n/a4pfc2QXA1101e4pfcA2LuxS, MPP, ThrRS/AlaRS common domainLuxS, MPP, ThrRS/AlaRS common domainLuxS/MPP-like metallohydrolasePeptidase_M16_M
P14735n/a4pfc2QXA1101e4pfcA4LuxS, MPP, ThrRS/AlaRS common domainLuxS, MPP, ThrRS/AlaRS common domainLuxS/MPP-like metallohydrolasePeptidase_M16_C,Peptidase_M16_M
P14735n/a4pfc2QXB1101e4pfcB1LuxS, MPP, ThrRS/AlaRS common domainLuxS, MPP, ThrRS/AlaRS common domainLuxS/MPP-like metallohydrolasePeptidase_M16_C,Peptidase_M16_M
P14735n/a4pfc2QXB1101e4pfcB3LuxS, MPP, ThrRS/AlaRS common domainLuxS, MPP, ThrRS/AlaRS common domainLuxS/MPP-like metallohydrolasePeptidase_M16_M
P14735n/a4pfc2QXB1101e4pfcB4LuxS, MPP, ThrRS/AlaRS common domainLuxS, MPP, ThrRS/AlaRS common domainLuxS/MPP-like metallohydrolasePeptidase_M16,Peptidase_M16_C