Attributes
UniProt ID
Protein Name
Insulin-degrading enzyme
Ligand Name
{(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-[(1-methyl-1H-imidazol-2-yl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl}methanol
DrugBank ID
None
PDB Ligand Accession
ChEMBL ID
n/a
PubChem ID
n/a
InChIKey
OJXBQVFJQWLDCX-NXCFDTQHSA-N
SMILES
Cc1cccc(c1C)c2ccc(cc2)C3C4CN(CCCCN4C3CO)S(=O)(=O)c5nccn5C
Drug Action
No data available
Affinity Metrics
No affinity data available
3D Structure
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Structure: 6EDS
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Color Legend
Unassigned regionsLigand / hetero atomse6edsA1e6edsA2e6edsA3e6edsA4e6edsB1e6edsB2e6edsB3e6edsB4
ECOD domains from experimental PDB structures interacting with ligand J22
| UniProt | DrugBank | PDB Ligand | PDB ID | ECOD Domain | Range Definition |
|---|---|---|---|---|---|
| P14735 | n/a | J22 | 6eds | e6edsA2 | A:43-286 |
| P14735 | n/a | J22 | 6eds | e6edsA4 | A:287-527 |
| P14735 | n/a | J22 | 6eds | e6edsB3 | B:287-527 |
| P14735 | n/a | J22 | 6eds | e6edsB4 | B:43-286 |
| P14735 | n/a | J22 | 6mq3 | e6mq3A2 | A:287-527 |
| P14735 | n/a | J22 | 6mq3 | e6mq3A3 | A:43-286 |
| P14735 | n/a | J22 | 6mq3 | e6mq3B3 | B:287-527 |
| P14735 | n/a | J22 | 6mq3 | e6mq3B4 | B:43-286 |