IRON/SULFUR CLUSTER

P18188 — Periplasmic hydrogenase large subunit

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand SF4

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand SF4

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
P18188	n/a	1frf	SF4	S	267	e1frfL2	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	1frf	SF4	S	267	e1frfL4	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	1yqw	SF4	A	267	e1yqwQ6	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	1yqw	SF4	A	267	e1yqwQ8	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	1yqw	SF4	B	267	e1yqwR5	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	1yqw	SF4	B	267	e1yqwR6	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	1yqw	SF4	B	267	e1yqwR8	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	1yqw	SF4	C	267	e1yqwS5	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	1yqw	SF4	C	267	e1yqwS6	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	1yqw	SF4	C	267	e1yqwS8	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	1yrq	SF4	A	267	e1yrqH6	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	1yrq	SF4	A	267	e1yrqH8	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	1yrq	SF4	B	267	e1yrqI6	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	1yrq	SF4	B	267	e1yrqI8	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	1yrq	SF4	C	267	e1yrqJ6	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	1yrq	SF4	C	267	e1yrqJ8	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	1yrq	SF4	D	267	e1yrqK6	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	1yrq	SF4	D	267	e1yrqK8	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	1yrq	SF4	F	267	e1yrqM6	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	1yrq	SF4	F	267	e1yrqM8	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	1yrq	SF4	G	267	e1yrqN5	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	1yrq	SF4	G	267	e1yrqN6	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	1yrq	SF4	G	267	e1yrqN8	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	3cur	SF4	A	267	e3curH2	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	3cur	SF4	A	267	e3curH4	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	3cur	SF4	B	267	e3curI2	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	3cur	SF4	B	267	e3curI4	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	3cur	SF4	C	267	e3curJ2	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	3cur	SF4	C	267	e3curJ4	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	3cus	SF4	A	267	e3cusQ2	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	3cus	SF4	A	267	e3cusQ4	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	3cus	SF4	B	267	e3cusR2	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	3cus	SF4	B	267	e3cusR3	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	3cus	SF4	B	267	e3cusR4	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	3cus	SF4	C	267	e3cusS2	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	3cus	SF4	C	267	e3cusS3	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	3cus	SF4	C	267	e3cusS4	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	3h3x	SF4	A	267	e3h3xQ2	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	3h3x	SF4	A	267	e3h3xQ4	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	3h3x	SF4	B	267	e3h3xR2	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	3h3x	SF4	B	267	e3h3xR3	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	3h3x	SF4	B	267	e3h3xR4	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	3h3x	SF4	C	267	e3h3xS2	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	3h3x	SF4	C	267	e3h3xS3	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	3h3x	SF4	C	267	e3h3xS4	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4ucx	SF4	A	1267	e4ucxQ2	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	4ucx	SF4	A	1267	e4ucxQ3	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4ucx	SF4	B	1267	e4ucxR1	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4ucx	SF4	B	1267	e4ucxR2	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	4ucx	SF4	C	1267	e4ucxS1	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4ucx	SF4	C	1267	e4ucxS3	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4ucx	SF4	C	1267	e4ucxS4	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	4uew	SF4	A	1267	e4uewQ1	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	4uew	SF4	A	1267	e4uewQ4	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4uew	SF4	B	1267	e4uewR2	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4uew	SF4	B	1267	e4uewR3	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4uew	SF4	B	1267	e4uewR4	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	4uew	SF4	C	1267	e4uewS1	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	4uew	SF4	C	1267	e4uewS3	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4uew	SF4	C	1267	e4uewS4	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4upe	SF4	A	1267	e4upeQ1	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4upe	SF4	A	1267	e4upeQ4	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	4upe	SF4	B	1267	e4upeR1	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	4upe	SF4	B	1267	e4upeR2	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4upe	SF4	B	1267	e4upeR3	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4upe	SF4	C	1267	e4upeS1	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	4upe	SF4	C	1267	e4upeS2	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4upe	SF4	C	1267	e4upeS3	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4uqp	SF4	A	1267	e4uqpQ2	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	4uqp	SF4	A	1267	e4uqpQ4	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4uqp	SF4	B	1267	e4uqpR1	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	alpha-helical domain in nickel-iron hydrogenase, large subunit	NiFeSe_Hases
P18188	n/a	4uqp	SF4	B	1267	e4uqpR2	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases
P18188	n/a	4uqp	SF4	B	1267	e4uqpR3	FAD-linked reductases, C-terminal domain-like	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	Ni-Fe binding domain in nickel-iron hydrogenase large subunit	NiFeSe_Hases