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Tucatinib

P21860 — Receptor tyrosine-protein kinase erbB-3

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand DB11652

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
P21860DB11652A1AACnD1207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsRecep_L_domain
P21860DB11652A1AACnD2389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainFurin-like
P21860DB11652A1AACnD3207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsRecep_L_domain,GF_recep_IV
P21860DB11652A1AACnD4389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainGF_recep_IV
P21860DB11652A1AACnD6206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePK_Tyr_Ser-Thr
Show other predicted domains (53)
PDB IDDomain NameECOD IDX GroupH GroupT GroupF Group
1M6Be1m6bA1207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e1m6bB1207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e1m6bB2207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e1m6bA2207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e1m6bA3389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
e1m6bB3389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
e1m6bB4389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
e1m6bA4389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
3KEXe3kexA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3kexB1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
3LMGe3lmgA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3lmgB1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
3P11e3p11A2207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e3p11A3207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e3p11A4389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
4LEOe4leoC1207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e4leoC4207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e4leoC2389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
e4leoC3389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
4P59e4p59A2207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e4p59A4207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e4p59A1389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
e4p59A3389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
4RIWe4riwA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e4riwC1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4RIXe4rixA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e4rixC1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4RIYe4riyA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e4riyC1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5CUSe5cusB1207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e5cusB2207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e5cusC1207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e5cusC4207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e5cusD2207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e5cusD4207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e5cusA1207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e5cusA3207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e5cusB3389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
e5cusB4389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
e5cusC2389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
e5cusC3389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
e5cusD1389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
e5cusD3389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
e5cusA2389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
e5cusA4389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
5O4Oe5o4oC1207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e5o4oC2389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
e5o4oC3389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
5O7Pe5o7pC1207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e5o7pC4207.1.1Single-stranded right-handed beta-helixLeucine-rich repeatsLeucine-rich repeatsLRR_1
e5o7pC2389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
e5o7pC3389.6.1EGF-likeGrowth factor receptor domainGrowth factor receptor domainIGFBP
6OP9e6op9A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase

ECOD domains from experimental PDB structures interacting with ligand DB11652

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
No experimental ECOD data found