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(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

P23458 — Tyrosine-protein kinase JAK1

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Attributes

UniProt ID
P23458
Protein Name
Tyrosine-protein kinase JAK1
Ligand Name
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
DrugBank ID
DB08877
PDB Ligand Accession
RXT
ChEMBL ID
CHEMBL1789941
PubChem ID
25126798
InChIKey
HFNKQEVNSGCOJV-OAHLLOKOSA-N
SMILES
c1c[nH]c2c1c(ncn2)c3cnn(c3)C(CC#N)C4CCCC4
Drug Action
inhibitor
Affinity Metrics
ki:0.09 nM
ic50:0.09 nM
kd:3.4 nM
ec50:24 nM