P23458
JAK1 — Tyrosine-protein kinase JAK1
Lists of molecules and drugs that interact with protein P23458
| DrugDomain Data | DrugBank ID | PDB Ligand | Ligand Name | ChEMBL | PubChem | InChIKey |
|---|---|---|---|---|---|---|
| Explore | DB02375 | MYC | 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE | CHEMBL164 | 5281672 | IKMDFBPHZNJCSN-UHFFFAOYSA-N |
| Explore | DB04272 | CIT | CITRIC ACID | CHEMBL1261 | 19782904;311;88113319 | KRKNYBCHXYNGOX-UHFFFAOYSA-N |
| Explore | DB04716 | IZA | 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE | CHEMBL21156 | 5494425 | VNDWQCSOSCCWIP-UHFFFAOYSA-N |
| Explore | DB08877 | RXT | (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile | CHEMBL1789941 | 25126798 | HFNKQEVNSGCOJV-OAHLLOKOSA-N |
| Explore | DB08895 | MI1 | 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | CHEMBL221959 | 9926791 | UJLAWZDWDVHWOW-YPMHNXCESA-N |
| Explore | DB09462 | GOL | GLYCEROL | CHEMBL692 | 753 | PEDCQBHIVMGVHV-UHFFFAOYSA-N |
| Explore | DB11817 | 3JW | Baricitinib | CHEMBL2105759 | 44205240 | XUZMWHLSFXCVMG-UHFFFAOYSA-N |
| Explore | DB12010 | 2RC | [6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate | CHEMBL2103830 | 11671467 | GKDRMWXFWHEQQT-UHFFFAOYSA-N |
| Explore | DB12500 | 2TA | N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide | CHEMBL1287853 | 16722836 | JOOXLOJCABQBSG-UHFFFAOYSA-N |
| Explore | DB14845 | 2HB | N-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | CHEMBL3301607 | 49831257 | RIJLVEAXPNLDTC-UHFFFAOYSA-N |
| Explore | DB14973 | D7D | N-{cis-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | CHEMBL3655081 | n/a | IUEWXNHSKRWHDY-PHIMTYICSA-N |
| Explore | DB15003 | G4J | [(1S)-2,2-difluorocyclopropyl][(1R,5S)-3-{2-[(1-methyl-1H-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | CHEMBL4297477 | 118878093 | BUWBRTXGQRBBHG-MJBXVCDLSA-N |
| Explore | DB15091 | n/a | Upadacitinib | n/a | n/a | n/a |
| Explore | DB15822 | Q4J | Pralsetinib | CHEMBL4297597 | n/a | GBLBJPZSROAGMF-BATDWUPUSA-N |
| Explore | DB16756 | n/a | Ivarmacitinib | n/a | n/a | n/a |
| Explore | DB16833 | ADP | ADENOSINE-5'-DIPHOSPHATE | CHEMBL14830 | 6022 | XTWYTFMLZFPYCI-KQYNXXCUSA-N |
| Explore | None | 0NH | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | CHEMBL2152409 | 56973424 | NWNODCMQDYQNDW-UHFFFAOYSA-N |
| Explore | None | 0NL | tert-butyl [(1R,3R)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)cyclopentyl]carbamate | CHEMBL2152296 | 53341503 | GAVWHEZXKOVIQY-VXGBXAGGSA-N |
| Explore | None | 0NT | [4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl)piperidin-1-yl][(2S)-1-(propan-2-yl)pyrrolidin-2-yl]methanone | CHEMBL2152405 | 53341544 | XDHQVHVOFHWRNB-SFHVURJKSA-N |
| Explore | None | 0Q2 | (1R,3R)-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(8H)-yl)cyclohexanol | None | 137347881 | IWJKSSOUXRKEPE-GHMZBOCLSA-N |
| Explore | None | 0UJ | N-({1-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl}methyl)methanesulfonamide | CHEMBL2206059 | 66557868 | IQHKHGHDPGFXAV-MISXGVKJSA-N |
| Explore | None | 15T | 3-(trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexyl)propanenitrile | CHEMBL2386636 | n/a | LLRNGFSFYHDPKW-MGPQQGTHSA-N |
| Explore | None | 1J5 | trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexanecarbonitrile | CHEMBL2386633 | n/a | ANDWOIMHOOWCLK-IJLUTSLNSA-N |
| Explore | None | 1J6 | (trans-4-{2-[(1R)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6H)-yl}cyclohexyl)acetonitrile | CHEMBL2386635 | n/a | IKSRDHMMQOCRHN-JHJVBQTASA-N |
| Explore | None | 1Q3 | (1R,2S)-2-{[8-oxo-2-(1H-pyrazol-4-yl)-5,8-dihydropyrido[3,4-d]pyrimidin-4-yl]amino}cyclopentanecarbonitrile | None | 137347978 | GGNYHYINELGWQU-CABZTGNLSA-N |
| Explore | None | 1Q4 | 4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-8(7H)-one | CHEMBL2434989 | 71737832 | FCTPOQHJQPWBOI-UHFFFAOYSA-N |
| Explore | None | 5JG | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-N-(piperidin-4-ylmethyl)-3H-imidazo[4,5-b]pyridin-7-amine | CHEMBL3746463 | 92045136 | IRGAIDAWHGYOKD-UHFFFAOYSA-N |
| Explore | None | 66P | 4-[(4-aminocyclohexyl)amino]-3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one | CHEMBL3780091 | n/a | JLWGOAGEDWMEBT-TXEJJXNPSA-N |
| Explore | None | 6TE | ~{N}-[3-[methyl(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | CHEMBL4100431 | n/a | QZOGHNDWZHFIJP-DTORHVGOSA-N |
| Explore | None | 9T6 | 4-[[(1S,3R)-5-oxidanyl-2-adamantyl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide | None | n/a | DREIJXJRTLTGJC-ZKVNVPQCSA-N |
| Explore | None | B7V | 3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3R,4S)-4-cyanooxan-3-yl]-1H-pyrazole-4-carboxamide | CHEMBL4071005 | 131839645 | MFWQXZZXOUIDTN-YGRLFVJLSA-N |
| Explore | None | BFK | [3-[[5-methyl-2-[[3-(4-methylpiperazin-1-yl)-5-methylsulfonyl-phenyl]amino]pyrimidin-4-yl]amino]phenyl]methanol | CHEMBL4171692 | 134817793 | WKJVLTJTBZVAKC-UHFFFAOYSA-N |
| Explore | None | C5I | 3-oxo-3-[(3R)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6H)-yl)piperidin-1-yl]propanenitrile | CHEMBL2392500 | n/a | COGIAVJREKAVDL-SNVBAGLBSA-N |
| Explore | None | EDO | 1,2-ETHANEDIOL | CHEMBL457299 | 174 | LYCAIKOWRPUZTN-UHFFFAOYSA-N |
| Explore | None | EYQ | ~{N}-[5-methyl-4-[7-[[(2~{R})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{H}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide | CHEMBL4588587 | 138376574 | IMKONRLYDLGQAV-MRXNPFEDSA-N |
| Explore | None | GYQ | 2-[4-[8-oxidanylidene-2-[(~{E})-(2-oxidanylidenepyridin-3-ylidene)amino]-7~{H}-purin-9-yl]cyclohexyl]ethanenitrile | None | n/a | JCBSNZZSUFHWSE-UGHOIBRWSA-N |
| Explore | None | JAK | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | CHEMBL2159141 | 57339437 | XTQACRIFOIASKV-UHFFFAOYSA-N |
| Explore | None | KEJ | N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | CHEMBL2178801 | 49856845 | PBBLZBUJHLNSRL-UHFFFAOYSA-N |
| Explore | None | KEP | N-{3-[5-chloro-2-(difluoromethoxy)phenyl]-1-methyl-1H-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | CHEMBL4777342 | 66847152 | CJXPNZXEEPSZHK-UHFFFAOYSA-N |
| Explore | None | KES | N-{5-[5-chloro-2-(difluoromethoxy)phenyl]-1H-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | CHEMBL4744172 | 118522410 | KHCFKCPXXJQHMH-UHFFFAOYSA-N |
| Explore | None | KEV | N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]-2-methyl-2H-pyrazolo[4,3-c]pyridine-7-carboxamide | CHEMBL4781423 | 137797031 | FCWWZBZYMGWKGY-UHFFFAOYSA-N |
| Explore | None | KEY | N-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-yl]-1H-pyrazolo[4,3-c]pyridine-7-carboxamide | CHEMBL4788474 | 137797032 | NBFASNUBTMTAFQ-UHFFFAOYSA-N |
| Explore | None | KF1 | N-[5-(3-methoxynaphthalen-2-yl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | CHEMBL4742382 | 137797033 | LGRPDWKAHUIEOE-UHFFFAOYSA-N |
| Explore | None | KF4 | N-[5-(6-methoxy-1H-indazol-5-yl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | CHEMBL4755725 | 138753291 | YENOZGNVRCRNCQ-UHFFFAOYSA-N |
| Explore | None | KGZ | 1-[(3~{R},4~{R})-4-(cyanomethyl)-1-[[4-(cyclohexen-1-yl)phenyl]methyl]-3-fluoranyl-piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | None | 146673491 | JZLQNFWWJFOUEZ-YWEHKCAJSA-N |
| Explore | None | KH5 | 1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | None | 132088493 | HKYCPTFBXARDTR-UHFFFAOYSA-N |
| Explore | None | KH8 | 1-[4-(cyanomethyl)-1-[(3-oxidanyl-4-phenyl-phenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | None | 132088394 | YQNPSYZTFUVTCR-UHFFFAOYSA-N |
| Explore | None | KHE | 1-[(3~{R},4~{R})-4-(cyanomethyl)-3-fluoranyl-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | None | 132088378 | MQWQEBHHQHORKK-YWEHKCAJSA-N |
| Explore | None | KHH | methyl ~{N}-[4-aminocarbonyl-1-[(3~{R},4~{R})-4-(cyanomethyl)-1-[(4-ethenyl-2-fluoranyl-5-oxidanyl-phenyl)methyl]-3-fluoranyl-piperidin-4-yl]pyrazol-3-yl]carbamate | None | 146673492 | KNQPQNPPLBJXJR-GCJKJVERSA-N |
| Explore | None | LKQ | ~{N}-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]-5-methyl-pyrimidin-4-yl]-1~{H}-indol-7-yl]-2-methyl-pyridine-3-carboxamide | CHEMBL4441479 | 146025986 | VVOKUJIAOSWPTI-UHFFFAOYSA-N |
| Explore | None | LKT | 2-chloranyl-6-[(3~{S})-3-[(1~{S})-2-cyano-1-[4-(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile | None | 59589095 | BKUZTJNOISYCFG-YWZLYKJASA-N |
| Explore | None | MG | MAGNESIUM ION | None | 888 | JLVVSXFLKOJNIY-UHFFFAOYSA-N |
| Explore | None | NA | SODIUM ION | None | 923 | FKNQFGJONOIPTF-UHFFFAOYSA-N |
| Explore | None | NTQ | (1~{S})-2,2-bis(fluoranyl)-~{N}-[4-(3-methyl-6-oxidanylidene-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]cyclopropane-1-carboxamide | CHEMBL4639973 | n/a | OWAGRTBSGRSEOG-NHCYSSNCSA-N |
| Explore | None | NTW | 2-[4-(3-methyl-6-oxidanylidene-1,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]ethanenitrile | CHEMBL4645814 | n/a | ZPCWQNHNXIMUEY-XYPYZODXSA-N |
| Explore | None | PEG | DI(HYDROXYETHYL)ETHER | CHEMBL1235226 | 8117 | MTHSVFCYNBDYFN-UHFFFAOYSA-N |
| Explore | None | R4S | N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropanecarboxamide | CHEMBL4640981 | 146018275 | GYRPAYDYHMZXQT-KZULUSFZSA-N |