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CHLORIDE ION

P27986 — Phosphatidylinositol 3-kinase regulatory subunit alpha

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand CL

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
P27986NoneCL000004141189.1.1GTPase activation domain, GAPGTPase activation domain, GAPGTPase activation domain, GAPRasGAP
P27986NoneCL000057356189.1.1GTPase activation domain, GAPGTPase activation domain, GAPGTPase activation domain, GAPRasGAP
Show other predicted domains (98)
PDB IDDomain NameECOD IDX GroupH GroupT GroupF Group
1H9Oe1h9oA1214.1.1SH2SH2SH2SH2
1PHTe1phtA14.1.1SH3SH3SH3SH3_1
1PICe1picA1214.1.1SH2SH2SH2SH2
1PKSe1pksA14.1.1SH3SH3SH3SH3_1
1PKTe1pktA14.1.1SH3SH3SH3SH3_1
2IUGe2iugA1214.1.1SH2SH2SH2SH2
2IUHe2iuhA1214.1.1SH2SH2SH2SH2
2IUIe2iuiA1214.1.1SH2SH2SH2SH2
e2iuiB1214.1.1SH2SH2SH2SH2
2RD0e2rd0B13755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
2V1Ye2v1yB13755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
3HHMe3hhmB1214.1.1SH2SH2SH2SH2
e3hhmB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
3HIZe3hizB1214.1.1SH2SH2SH2SH2
e3hizB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
3I5Re3i5rA14.1.1SH3SH3SH3SH3_1
3I5Se3i5sA14.1.1SH3SH3SH3SH3_1
e3i5sB14.1.1SH3SH3SH3SH3_1
e3i5sC14.1.1SH3SH3SH3SH3_1
e3i5sD14.1.1SH3SH3SH3SH3_1
4A55e4a55B13755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
4JPSe4jpsB2214.1.1SH2SH2SH2SH2
e4jpsB33755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
4L1Be4l1bB1214.1.1SH2SH2SH2SH2
e4l1bB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
4L23e4l23B1214.1.1SH2SH2SH2SH2
e4l23B23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
4L2Ye4l2yB1214.1.1SH2SH2SH2SH2
e4l2yB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
4OVUe4ovuB1214.1.1SH2SH2SH2SH2
e4ovuB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
4OVVe4ovvB1214.1.1SH2SH2SH2SH2
e4ovvB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
4WAFe4wafB1214.1.1SH2SH2SH2SH2
e4wafB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
4YKNe4yknA6214.1.1SH2SH2SH2SH2
e4yknA53755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
4ZOPe4zopB1214.1.1SH2SH2SH2SH2
e4zopB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5AULe5aulA1214.1.1SH2SH2SH2SH2
5FI4e5fi4B2214.1.1SH2SH2SH2SH2
e5fi4B33755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5GJIe5gjiA1214.1.1SH2SH2SH2SH2
5ITDe5itdB2214.1.1SH2SH2SH2SH2
e5itdB13755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5M6Ue5m6uB13755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SW8e5sw8B1214.1.1SH2SH2SH2SH2
e5sw8B23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SWGe5swgB1214.1.1SH2SH2SH2SH2
e5swgB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SWOe5swoB2214.1.1SH2SH2SH2SH2
e5swoB33755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SWPe5swpB2214.1.1SH2SH2SH2SH2
e5swpB33755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SWRe5swrB2214.1.1SH2SH2SH2SH2
e5swrB33755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SWTe5swtB1214.1.1SH2SH2SH2SH2
e5swtB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SX8e5sx8B1214.1.1SH2SH2SH2SH2
e5sx8B23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SX9e5sx9B1214.1.1SH2SH2SH2SH2
e5sx9B23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SXAe5sxaB1214.1.1SH2SH2SH2SH2
e5sxaB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SXBe5sxbB2214.1.1SH2SH2SH2SH2
e5sxbB33755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SXCe5sxcB1214.1.1SH2SH2SH2SH2
e5sxcB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SXDe5sxdB2214.1.1SH2SH2SH2SH2
e5sxdB33755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SXEe5sxeB2214.1.1SH2SH2SH2SH2
e5sxeB33755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SXFe5sxfB1214.1.1SH2SH2SH2SH2
e5sxfB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SXIe5sxiB1214.1.1SH2SH2SH2SH2
e5sxiB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SXJe5sxjB1214.1.1SH2SH2SH2SH2
e5sxjB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5SXKe5sxkB1214.1.1SH2SH2SH2SH2
e5sxkB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5UBTe5ubtB13755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5UK8e5uk8B1214.1.1SH2SH2SH2SH2
e5uk8B23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5UKJe5ukjB1214.1.1SH2SH2SH2SH2
e5ukjB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5UL1e5ul1B1214.1.1SH2SH2SH2SH2
e5ul1B23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5VLRe5vlrB13755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5XGHe5xghB1214.1.1SH2SH2SH2SH2
e5xghB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5XGIe5xgiB1214.1.1SH2SH2SH2SH2
e5xgiB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
5XGJe5xgjB1214.1.1SH2SH2SH2SH2
e5xgjB23755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
6NCTe6nctB2214.1.1SH2SH2SH2SH2
e6nctB13755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
6PYRe6pyrB13755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2
6PYUe6pyuB13755.4.1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2

ECOD domains from experimental PDB structures interacting with ligand CL

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
P27986n/a7lq1CLA1102e7lq1B1YscO-likePhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPhosphatidylinositol 3-kinase regulatory subunit inter-SH2 domainPI3K_P85_iSH2