2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]-4-[1-AMINO-1-(1-METHYL-1H-IMIDIZOL-5-YL)-ETHYL]-BENZONITRILE

P49354 — Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand BNE

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
P49354	None	BNE	000004533	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
P49354	None	BNE	000059647	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3

Show other predicted domains (11)

PDB ID	Domain Name	ECOD ID	X Group	H Group	T Group	F Group
1JCQ	e1jcqA1	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
1LD7	e1ld7A1	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
1LD8	e1ld8A1	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
1S63	e1s63A1	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
1TN6	e1tn6A1	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
2F0Y	e2f0yA1	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
2H6G	e2h6gA1	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
2H6H	e2h6hA1	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
2H6I	e2h6iA1	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
2IEJ	e2iejA1	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3
3E37	e3e37A1	109.4.1	Repetitive alpha hairpins	ARM repeat	ARM repeat	14-3-3

ECOD domains from experimental PDB structures interacting with ligand BNE

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
P49354	n/a	1mzc	BNE	B	1003	e1mzcA1	Repetitive alpha hairpins	ARM repeat	ARM repeat	PPTA