(1R,3S,4S,5R)-3-{4-amino-3-fluoro-5-[(1,1,1,3,3,3-hexafluoropropan-2-yl)oxy]benzyl}-5-[(3-tert-butylbenzyl)amino]tetrahydro-2H-thiopyran-4-ol 1-oxide
P56817 — Beta-secretase 1
ECOD Domain Annotations
ECOD domains from AlphaFold model interacting with ligand 1YS
| UniProt | DrugBank | PDB Ligand | Domain Label | ECOD ID | X Group | H Group | T Group | F Group |
|---|---|---|---|---|---|---|---|---|
| No predicted ECOD data found | ||||||||
ECOD domains from experimental PDB structures interacting with ligand 1YS
| UniProt | DrugBank | PDB ID | Ligand Acc. | Chain | Res No. | Exp. Domain | X Group | H Group | T Group | F Group |
|---|---|---|---|---|---|---|---|---|---|---|
| P56817 | n/a | 4lxa | 1YS | A | 501 | e4lxaA2 | cradle loop barrel | RIFT-related | acid protease | Asp |
| P56817 | n/a | 4lxa | 1YS | A | 501 | e4lxaA3 | cradle loop barrel | RIFT-related | acid protease | Asp |
| P56817 | n/a | 4lxa | 1YS | B | 502 | e4lxaB2 | cradle loop barrel | RIFT-related | acid protease | Asp |
| P56817 | n/a | 4lxa | 1YS | B | 502 | e4lxaB3 | cradle loop barrel | RIFT-related | acid protease | Asp |
| P56817 | n/a | 4lxa | 1YS | C | 501 | e4lxaC2 | cradle loop barrel | RIFT-related | acid protease | Asp |
| P56817 | n/a | 4lxa | 1YS | C | 501 | e4lxaC3 | cradle loop barrel | RIFT-related | acid protease | Asp |