DrugDomain logoDrugDomain

Spebrutinib

Q06187 — Tyrosine-protein kinase BTK

← Back

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand DB11764

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
Q06187DB11764n/anD1220.1.1PH domain-likePH domain-likePH domain-likePH
Q06187DB11764n/anD2398.1.1Btk/CHORD zinc fingersBtk/CHORD zinc fingersBtk/CHORD zinc fingersBTK
Q06187DB11764n/anD5206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePK_Tyr_Ser-Thr
Show other predicted domains (113)
PDB IDDomain NameECOD IDX GroupH GroupT GroupF Group
1AWWe1awwA14.1.1SH3SH3SH3SH3_1
1AWXe1awxA14.1.1SH3SH3SH3SH3_1
1B55e1b55A1220.1.1PH domain-likePH domain-likePH domain-likePH
e1b55B1220.1.1PH domain-likePH domain-likePH domain-likePH
e1b55A2398.1.1Btk/CHORD zinc fingersBtk/CHORD zinc fingersBtk/CHORD zinc fingersBTK
e1b55B2398.1.1Btk/CHORD zinc fingersBtk/CHORD zinc fingersBtk/CHORD zinc fingersBTK
1BTKe1btkA1220.1.1PH domain-likePH domain-likePH domain-likePH
e1btkB1220.1.1PH domain-likePH domain-likePH domain-likePH
e1btkA2398.1.1Btk/CHORD zinc fingersBtk/CHORD zinc fingersBtk/CHORD zinc fingersBTK
e1btkB2398.1.1Btk/CHORD zinc fingersBtk/CHORD zinc fingersBtk/CHORD zinc fingersBTK
1BWNe1bwnB1220.1.1PH domain-likePH domain-likePH domain-likePH
e1bwnA1220.1.1PH domain-likePH domain-likePH domain-likePH
e1bwnB2398.1.1Btk/CHORD zinc fingersBtk/CHORD zinc fingersBtk/CHORD zinc fingersBTK
e1bwnA2398.1.1Btk/CHORD zinc fingersBtk/CHORD zinc fingersBtk/CHORD zinc fingersBTK
1K2Pe1k2pB1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e1k2pA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
1QLYe1qlyA14.1.1SH3SH3SH3SH3_1
2GE9e2ge9A1214.1.1SH2SH2SH2SH2
2Z0Pe2z0pB1220.1.1PH domain-likePH domain-likePH domain-likePH
e2z0pD1220.1.1PH domain-likePH domain-likePH domain-likePH
e2z0pA1220.1.1PH domain-likePH domain-likePH domain-likePH
e2z0pC1220.1.1PH domain-likePH domain-likePH domain-likePH
e2z0pC2398.1.1Btk/CHORD zinc fingersBtk/CHORD zinc fingersBtk/CHORD zinc fingersBTK
e2z0pB2398.1.1Btk/CHORD zinc fingersBtk/CHORD zinc fingersBtk/CHORD zinc fingersBTK
e2z0pA2398.1.1Btk/CHORD zinc fingersBtk/CHORD zinc fingersBtk/CHORD zinc fingersBTK
e2z0pD2398.1.1Btk/CHORD zinc fingersBtk/CHORD zinc fingersBtk/CHORD zinc fingersBTK
3GENe3genA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
3K54e3k54A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
3OCSe3ocsA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
3OCTe3octA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
3P08e3p08A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e3p08B1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
3PIXe3pixA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
3PIYe3piyA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
3PIZe3pizA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
3PJ1e3pj1A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
3PJ2e3pj2A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
3PJ3e3pj3A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4NWMe4nwmA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e4nwmB1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4OT5e4ot5A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4OT6e4ot6A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4OTFe4otfA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4OTQe4otqA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4OTRe4otrA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4RFYe4rfyA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4RFZe4rfzA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4RG0e4rg0A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4RX5e4rx5A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4YHFe4yhfA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e4yhfB1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4Z3Ve4z3vA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4ZLYe4zlyA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
4ZLZe4zlzA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5BPYe5bpyA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5bpyB1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5BQ0e5bq0A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5FBNe5fbnC1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5fbnD1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5FBOe5fboA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5J87e5j87A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5j87B1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5j87C1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5j87D1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5JRSe5jrsA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5jrsB1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5KUPe5kupA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5P9Fe5p9fA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5P9Ge5p9gA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5P9He5p9hA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5P9Ie5p9iA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5P9Je5p9jA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5P9Ke5p9kA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5P9Le5p9lA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5P9Me5p9mA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5T18e5t18A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5U9De5u9dA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5VFIe5vfiA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5VGOe5vgoA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5XYZe5xyzA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5xyzB1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
5ZZ4e5zz4B1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5zz4A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5zz4C1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5zz4D1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5zz4E1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e5zz4F1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6AUAe6auaA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6AUBe6aubA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6BIKe6bikA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6BKEe6bkeA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6BKHe6bkhA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6BKWe6bkwA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6BLNe6blnA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6DI0e6di0A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6DI1e6di1A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6DI3e6di3A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6DI5e6di5A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6DI9e6di9A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6E4Fe6e4fA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6EP9e6ep9A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6HRPe6hrpA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6HRTe6hrtA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6J6Me6j6mA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6N9Pe6n9pA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6NFHe6nfhA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6NFIe6nfiA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6NZMe6nzmA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e6nzmD1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6O8Ie6o8iA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6OMUe6omuA1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
6S90e6s90A1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase
e6s90B1206.1.1Protein kinase/SAICAR synthase/ATP-graspProtein kinase/SAICAR synthase/ATP-graspProtein kinasePkinase

ECOD domains from experimental PDB structures interacting with ligand DB11764

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
No experimental ECOD data found