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Attributes

UniProt ID
Q07422
Protein Name
Bifunctional dihydrofolate reductase-thymidylate synthase
Ligand Name
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
DrugBank ID
DB02338
PDB Ligand Accession
NDP
ChEMBL ID
n/a
PubChem ID
n/a
InChIKey
ACFIXJIJDZMPPO-NNYOXOHSSA-N
SMILES
c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=CCC(=C5)C(=O)N)O)O)O)OP(=O)(O)O)N
Drug Action
No data available
Affinity Metrics
No affinity data available

3D Structure

Interactive Mol* view for the current protein-molecule pair.

Mol*
Structure: 4ECK
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Color Legend
Unassigned regionsLigand / hetero atomse4eckA2e4eckA3e4eckB2e4eckB3
ECOD domains from experimental PDB structures interacting with ligand DB02338
UniProtDrugBankPDB LigandPDB IDECOD DomainRange Definition
Q07422DB02338NDP4ecke4eckA2A:3-44,A:74-193,A:226-251
Q07422DB02338NDP4ecke4eckB2B:3-44,B:74-193,B:226-251
Q07422DB02338NDP4eile4eilA3A:4-252
Q07422DB02338NDP4eile4eilB2B:3-251
Q07422DB02338NDP4eile4eilC5C:4-252
Q07422DB02338NDP4eile4eilD2D:3-251
Q07422DB02338NDP4eile4eilE5E:4-252
Q07422DB02338NDP4eile4eilF3F:3-251
Q07422DB02338NDP4eile4eilG5G:4-252
Q07422DB02338NDP4eile4eilH2H:3-251
Q07422DB02338NDP4ky4e4ky4A2A:3-41,A:74-193,A:226-242
Q07422DB02338NDP4ky4e4ky4B2B:3-41,B:74-193,B:226-242
Q07422DB02338NDP4ky4e4ky4C2C:3-41,C:74-193,C:226-242
Q07422DB02338NDP4ky4e4ky4D2D:3-41,D:74-193,D:226-242
Q07422DB02338NDP4ky4e4ky4E2E:3-41,E:74-193,E:226-242
Q07422DB02338NDP4ky4e4ky4F2F:3-41,F:74-193,F:226-242
Q07422DB02338NDP4ky4e4ky4G2G:3-41,G:74-193,G:226-242
Q07422DB02338NDP4ky4e4ky4H2H:3-41,H:74-193,H:226-242
Q07422DB02338NDP4kyae4kyaA2A:4-252
Q07422DB02338NDP4kyae4kyaB2B:3-251
Q07422DB02338NDP4kyae4kyaC2C:4-252
Q07422DB02338NDP4kyae4kyaD2D:3-251
Q07422DB02338NDP4kyae4kyaE2E:4-252
Q07422DB02338NDP4kyae4kyaF2F:3-251
Q07422DB02338NDP4kyae4kyaG2G:4-252
Q07422DB02338NDP4kyae4kyaH3H:3-251
Q07422DB02338NDP5t0le5t0lA1A:4-252
Q07422DB02338NDP5t0le5t0lB2B:4-252
Q07422DB02338NDP6aoge6aogA1A:3-252
Q07422DB02338NDP6aoge6aogB1B:4-252
Q07422DB02338NDP6aohe6aohA2A:3-252
Q07422DB02338NDP6aohe6aohB2B:4-252
Q07422DB02338NDP6aoie6aoiA1A:3-252
Q07422DB02338NDP6aoie6aoiB2B:4-252
Q07422DB02338NDP6n1se6n1sA1A:3-252
Q07422DB02338NDP6n1se6n1sB2B:4-252
Q07422DB02338NDP6n1te6n1tA2A:3-252
Q07422DB02338NDP6n1te6n1tB1B:4-252
Q07422DB02338NDP7fgwe7fgwA2A:1-48,A:74-200,A:220-257
Q07422DB02338NDP7fgwe7fgwB2B:2-48,B:74-200,B:220-256
Q07422DB02338NDP7fgwe7fgwC2C:2-48,C:74-200,C:220-254
Q07422DB02338NDP7fgwe7fgwD1D:1-48,D:74-200,D:220-258
Q07422DB02338NDP7fgxe7fgxA2A:1-48,A:74-200,A:220-257
Q07422DB02338NDP7fgxe7fgxB2B:1-48,B:74-200,B:220-255
Q07422DB02338NDP7fgxe7fgxC1C:1-48,C:74-200,C:220-255
Q07422DB02338NDP7fgxe7fgxD2D:1-48,D:74-200,D:220-258
Q07422DB02338NDP7fgye7fgyA2A:2-48,A:74-200,A:220-257
Q07422DB02338NDP7fgye7fgyB1B:2-48,B:74-200,B:220-258
Q07422DB02338NDP7fgye7fgyC1C:2-48,C:74-200,C:220-255
Q07422DB02338NDP7fgye7fgyD1D:2-48,D:74-200,D:220-258