[6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate

Q14289 — Protein-tyrosine kinase 2-beta

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand DB12010

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
Q14289	DB12010	2RC	nD1	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	FERM_N_2
Q14289	DB12010	2RC	nD2	197.1.1	Acyl-CoA binding protein-like	Acyl-CoA binding protein-like	Acyl-CoA binding protein-like	FERM_M
Q14289	DB12010	2RC	nD4	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	PK_Tyr_Ser-Thr
Q14289	DB12010	2RC	nD5	601.1.2	Four-helical up-and-down bundle	alpha-catenin-related	I/LWEQ domain (Pfam 01608)	n/a

Show other predicted domains (30)

PDB ID	Domain Name	ECOD ID	X Group	H Group	T Group	F Group
2LK4	e2lk4A1	601.16.1	Four-helical up-and-down bundle	FAT domain of focal adhesion kinase	FAT domain of focal adhesion kinase	Focal_AT
3CC6	e3cc6A1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
3ET7	e3et7A1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
3FZO	e3fzoA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
3FZP	e3fzpA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
3FZR	e3fzrA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
3FZS	e3fzsA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
3FZT	e3fztA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
3GM1	e3gm1A1	601.16.1	Four-helical up-and-down bundle	FAT domain of focal adhesion kinase	FAT domain of focal adhesion kinase	Focal_AT
3GM1	e3gm1B1	601.16.1	Four-helical up-and-down bundle	FAT domain of focal adhesion kinase	FAT domain of focal adhesion kinase	Focal_AT
3GM2	e3gm2A1	601.16.1	Four-helical up-and-down bundle	FAT domain of focal adhesion kinase	FAT domain of focal adhesion kinase	Focal_AT
3GM3	e3gm3A1	601.16.1	Four-helical up-and-down bundle	FAT domain of focal adhesion kinase	FAT domain of focal adhesion kinase	Focal_AT
3H3C	e3h3cA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
3U3F	e3u3fB1	601.16.1	Four-helical up-and-down bundle	FAT domain of focal adhesion kinase	FAT domain of focal adhesion kinase	Focal_AT
	e3u3fA1	601.16.1	Four-helical up-and-down bundle	FAT domain of focal adhesion kinase	FAT domain of focal adhesion kinase	Focal_AT
	e3u3fC1	601.16.1	Four-helical up-and-down bundle	FAT domain of focal adhesion kinase	FAT domain of focal adhesion kinase	Focal_AT
	e3u3fD1	601.16.1	Four-helical up-and-down bundle	FAT domain of focal adhesion kinase	FAT domain of focal adhesion kinase	Focal_AT
4EKU	e4ekuA1	197.1.1	Acyl-CoA binding protein-like	Acyl-CoA binding protein-like	Acyl-CoA binding protein-like	FERM_M
	e4ekuA4	220.1.1	PH domain-like	PH domain-like	PH domain-like	PH
	e4ekuA3	221.1.1	beta-Grasp	Ubiquitin-related	Ubiquitin-like	Fer2
4H1J	e4h1jA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
4H1M	e4h1mA2	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
4R32	e4r32A1	601.16.1	Four-helical up-and-down bundle	FAT domain of focal adhesion kinase	FAT domain of focal adhesion kinase	Focal_AT
4XEF	e4xefA1	601.16.1	Four-helical up-and-down bundle	FAT domain of focal adhesion kinase	FAT domain of focal adhesion kinase	Focal_AT
4XEF	e4xefD1	601.16.1	Four-helical up-and-down bundle	FAT domain of focal adhesion kinase	FAT domain of focal adhesion kinase	Focal_AT
4XEK	e4xekA1	601.16.1	Four-helical up-and-down bundle	FAT domain of focal adhesion kinase	FAT domain of focal adhesion kinase	Focal_AT
4XEV	e4xevA1	601.16.1	Four-helical up-and-down bundle	FAT domain of focal adhesion kinase	FAT domain of focal adhesion kinase	Focal_AT
4XEV	e4xevD1	601.16.1	Four-helical up-and-down bundle	FAT domain of focal adhesion kinase	FAT domain of focal adhesion kinase	Focal_AT
5TO8	e5to8A1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase
5TOB	e5tobA1	206.1.1	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase/SAICAR synthase/ATP-grasp	Protein kinase	Pkinase

ECOD domains from experimental PDB structures interacting with ligand DB12010

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
No experimental ECOD data found