Attributes
UniProt ID
Protein Name
Histone-lysine N-methyltransferase EZH2
Ligand Name
1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide
DrugBank ID
None
PDB Ligand Accession
ChEMBL ID
n/a
PubChem ID
n/a
InChIKey
MNZANYNOXFULDI-GCJKJVERSA-N
SMILES
Cc1c(c2ccccc2n1C(C)C3CCN(CC3)CC(C)(F)F)C(=O)NCC4C(=CC(=NC4=O)C)OC
Drug Action
No data available
Affinity Metrics
No affinity data available
3D Structure
Interactive Mol* view for the current protein-molecule pair.
Structure: 5LS6
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Color Legend
Unassigned regionsLigand / hetero atomse5ls6A1e5ls6A2e5ls6A3e5ls6A4e5ls6A5e5ls6A6e5ls6A7e5ls6B1e5ls6C1e5ls6D1e5ls6D2e5ls6D3e5ls6D4e5ls6D6e5ls6D7e5ls6D8e5ls6E1e5ls6F1e5ls6G1e5ls6G2e5ls6G3e5ls6G4e5ls6G5e5ls6G6e5ls6G7e5ls6H1e5ls6I1e5ls6J1e5ls6J2e5ls6J3e5ls6J4e5ls6J5e5ls6J6e5ls6J7e5ls6K1e5ls6L1
ECOD domains from experimental PDB structures interacting with ligand 74D
| UniProt | DrugBank | PDB Ligand | PDB ID | ECOD Domain | Range Definition |
|---|---|---|---|---|---|
| Q15910 | n/a | 74D | 5ls6 | e5ls6A2 | A:10-157 |
| Q15910 | n/a | 74D | 5ls6 | e5ls6A3 | A:606-728 |
| Q15910 | n/a | 74D | 5ls6 | e5ls6D1 | D:606-728 |
| Q15910 | n/a | 74D | 5ls6 | e5ls6D3 | D:10-157 |
| Q15910 | n/a | 74D | 5ls6 | e5ls6G1 | G:10-157 |
| Q15910 | n/a | 74D | 5ls6 | e5ls6G5 | G:158-249 |
| Q15910 | n/a | 74D | 5ls6 | e5ls6G6 | G:606-730 |
| Q15910 | n/a | 74D | 5ls6 | e5ls6J4 | J:10-157 |
| Q15910 | n/a | 74D | 5ls6 | e5ls6J7 | J:606-728 |