Attributes
UniProt ID
Protein Name
DNA topoisomerase 4 subunit B
Ligand Name
3-amino-7-{(3R)-3-[(1S)-1-aminoethyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-8-methylquinazoline-2,4(1H,3H)-dione
DrugBank ID
None
PDB Ligand Accession
ChEMBL ID
n/a
PubChem ID
n/a
InChIKey
SMONLCFJGCJROJ-WDEREUQCSA-N
SMILES
Cc1c2c(cc(c1N3CCC(C3)C(C)N)F)C(=O)N(C(=O)N2C4CC4)N
Drug Action
No data available
Affinity Metrics
No affinity data available
3D Structure
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Structure: 3LTN
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Color Legend
Unassigned regionsLigand / hetero atomse3ltnA4e3ltnA5e3ltnA6e3ltnB4e3ltnB5e3ltnB6e3ltnC1e3ltnC2e3ltnD1e3ltnD2
ECOD domains from experimental PDB structures interacting with ligand PDQ
| UniProt | DrugBank | PDB Ligand | PDB ID | ECOD Domain | Range Definition |
|---|---|---|---|---|---|
| Q59961 | n/a | PDQ | 3ltn | e3ltnC2 | C:415-540,C:583-638 |
| Q59961 | n/a | PDQ | 3ltn | e3ltnD2 | D:415-540,D:583-638 |
| Q59961 | n/a | PDQ | 3raf | e3rafC1 | C:415-541,C:578-640 |
| Q59961 | n/a | PDQ | 3raf | e3rafD1 | D:415-541,D:578-640 |
| Q59961 | n/a | PDQ | 4z4q | e4z4qA4 | A:1007-1156 |
| Q59961 | n/a | PDQ | 4z4q | e4z4qA5 | A:415-640 |
| Q59961 | n/a | PDQ | 4z4q | e4z4qB2 | B:1007-1156 |
| Q59961 | n/a | PDQ | 4z4q | e4z4qB4 | B:415-640 |