DrugDomain logoDrugDomain

(2E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1R)-1-(2-methylpropyl)phthalazin-2(1H)-yl]prop-2 -en-1-one

Q81R22 — Dihydrofolate reductase

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand 52I

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand 52I

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
Q81R22n/a4elg52IB204e4elgB1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
Q81R22n/a4elg52IG204e4elgG1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1