DrugDomain logoDrugDomain

(2E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1S)-1-(2-methylpropyl)phthalazin-2(1H)-yl]prop-2-en-1-one

Q81R22 Dihydrofolate reductase

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand 52J

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand 52J

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
Q81R22n/a4elg52JA201e4elgA1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
Q81R22n/a4elg52JB201e4elgB1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
Q81R22n/a4elg52JC201e4elgC1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
Q81R22n/a4elg52JD201e4elgD1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
Q81R22n/a4elg52JE201e4elgE1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
Q81R22n/a4elg52JF201e4elgF1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
Q81R22n/a4elg52JG201e4elgG1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
Q81R22n/a4elg52JH201e4elgH1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1