DrugDomain logoDrugDomain

(2E)-3-{5-[(2,4-diaminopyrimidin-5-yl)methyl]-2,3-dimethoxyphenyl}-1-[(1R)-1-(2-methylprop-1-en-1-yl)phthalazin-2(1H)-y l]prop-2-en-1-one

Q81R22 Dihydrofolate reductase

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ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand 53I

UniProtDrugBankPDB LigandDomain LabelECOD IDX GroupH GroupT GroupF Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand 53I

UniProtDrugBankPDB IDLigand Acc.ChainRes No.Exp. DomainX GroupH GroupT GroupF Group
Q81R22n/a4elh53IA202e4elhA1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
Q81R22n/a4elh53IB202e4elhB1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
Q81R22n/a4elh53IC202e4elhC1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
Q81R22n/a4elh53ID201e4elhD1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
Q81R22n/a4elh53IE201e4elhE1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
Q81R22n/a4elh53IF201e4elhF1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
Q81R22n/a4elh53IG201e4elhG1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1
Q81R22n/a4elh53IH201e4elhH1Dihydrofolate reductasesDihydrofolate reductasesDihydrofolate reductasesDHFR_1