ACETYL COENZYME *A

Q8NRC3 — 2-oxoglutarate dehydrogenase E1/E2 component

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand ACO

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand ACO

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
Q8NRC3	n/a	8p5s	ACO	A	1303	e8p5sA1	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5s	ACO	A	1303	e8p5sA3	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5t	ACO	A	1302	e8p5tA1	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5t	ACO	A	1302	e8p5tA4	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5t	ACO	B	1302	e8p5tB1	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5t	ACO	B	1302	e8p5tB3	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5t	ACO	C	1302	e8p5tC2	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5t	ACO	C	1302	e8p5tC3	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5t	ACO	D	1302	e8p5tD2	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5t	ACO	D	1302	e8p5tD4	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5t	ACO	E	1302	e8p5tE2	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5t	ACO	E	1302	e8p5tE3	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5t	ACO	F	1302	e8p5tF1	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5t	ACO	F	1302	e8p5tF4	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5u	ACO	A	1303	e8p5uA2	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5u	ACO	A	1303	e8p5uA3	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5u	ACO	B	1303	e8p5uB1	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5u	ACO	B	1303	e8p5uB4	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5u	ACO	C	1303	e8p5uC1	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5u	ACO	C	1303	e8p5uC4	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5u	ACO	D	1303	e8p5uD1	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5u	ACO	D	1303	e8p5uD3	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5u	ACO	E	1303	e8p5uE2	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5u	ACO	E	1303	e8p5uE4	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5u	ACO	F	1303	e8p5uF3	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5u	ACO	F	1303	e8p5uF4	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5v	ACO	A	1302	e8p5vA2	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5v	ACO	A	1302	e8p5vA4	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5v	ACO	B	1302	e8p5vB3	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5v	ACO	B	1302	e8p5vB4	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5v	ACO	C	1302	e8p5vC2	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5v	ACO	C	1302	e8p5vC4	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5v	ACO	D	1302	e8p5vD2	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5v	ACO	D	1302	e8p5vD4	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5v	ACO	E	1302	e8p5vE1	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5v	ACO	E	1302	e8p5vE2	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5v	ACO	F	1302	e8p5vF1	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5v	ACO	F	1302	e8p5vF3	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5w	ACO	A	1302	e8p5wA1	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5w	ACO	A	1302	e8p5wA3	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5w	ACO	B	1302	e8p5wB2	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5w	ACO	B	1302	e8p5wB3	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5w	ACO	C	1302	e8p5wC3	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5w	ACO	C	1302	e8p5wC4	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5w	ACO	D	1302	e8p5wD2	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5w	ACO	D	1302	e8p5wD3	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5w	ACO	E	1302	e8p5wE3	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5w	ACO	E	1302	e8p5wE4	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr
Q8NRC3	n/a	8p5w	ACO	F	1302	e8p5wF1	TK C-terminal domain-like	TK C-terminal domain-like	TK C-terminal domain-like	OxoGdeHyase_C
Q8NRC3	n/a	8p5w	ACO	F	1302	e8p5wF4	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Thiamin diphosphate-binding fold (THDP-binding)	Transket_pyr