1,2-ETHANEDIOL

Q8T5T8 — Bifunctional dihydrofolate reductase-thymidylate synthase

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand EDO

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand EDO

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
Q8T5T8	n/a	3hbb	EDO	A	904	e3hbbA2	Dihydrofolate reductases	Dihydrofolate reductases	Dihydrofolate reductases	DHFR_1
Q8T5T8	n/a	3hbb	EDO	A	904	e3hbbB1	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylat_synt
Q8T5T8	n/a	3hbb	EDO	B	906	e3hbbA1	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylat_synt
Q8T5T8	n/a	3hbb	EDO	B	906	e3hbbA2	Dihydrofolate reductases	Dihydrofolate reductases	Dihydrofolate reductases	DHFR_1
Q8T5T8	n/a	3hbb	EDO	B	906	e3hbbB1	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylat_synt
Q8T5T8	n/a	3hbb	EDO	B	906	e3hbbC1	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylat_synt
Q8T5T8	n/a	3hbb	EDO	C	912	e3hbbB1	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylat_synt
Q8T5T8	n/a	3hbb	EDO	C	912	e3hbbC1	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylat_synt
Q8T5T8	n/a	3hbb	EDO	C	912	e3hbbD1	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylat_synt
Q8T5T8	n/a	3hbb	EDO	C	912	e3hbbD2	Dihydrofolate reductases	Dihydrofolate reductases	Dihydrofolate reductases	DHFR_1
Q8T5T8	n/a	3hbb	EDO	D	911	e3hbbC1	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylat_synt
Q8T5T8	n/a	3hbb	EDO	D	911	e3hbbD1	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylat_synt
Q8T5T8	n/a	3hbb	EDO	D	911	e3hbbD2	Dihydrofolate reductases	Dihydrofolate reductases	Dihydrofolate reductases	DHFR_1
Q8T5T8	n/a	3kjs	EDO	A	907	e3kjsA1	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylat_synt
Q8T5T8	n/a	3kjs	EDO	B	912	e3kjsA1	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylat_synt
Q8T5T8	n/a	3kjs	EDO	B	912	e3kjsB1	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylat_synt
Q8T5T8	n/a	3kjs	EDO	C	913	e3kjsC2	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylat_synt
Q8T5T8	n/a	3kjs	EDO	D	911	e3kjsD1	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylate synthase/dCMP hydroxymethylase	Thymidylat_synt