ZINC ION

Q8TBC4 — NEDD8-activating enzyme E1 catalytic subunit

ECOD Domain Annotations

ECOD domains from AlphaFold model interacting with ligand ZN

UniProt	DrugBank	PDB Ligand	Domain Label	ECOD ID	X Group	H Group	T Group	F Group
No predicted ECOD data found

ECOD domains from experimental PDB structures interacting with ligand ZN

UniProt	DrugBank	PDB ID	Ligand Acc.	Chain	Res No.	Exp. Domain	X Group	H Group	T Group	F Group
Q8TBC4	n/a	1r4m	ZN	F	3	e1r4mF3	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	1r4m	ZN	F	3	e1r4mF4	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	1r4m	ZN	H	4	e1r4mH3	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	1r4m	ZN	H	4	e1r4mH4	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	1r4m	ZN	J	2	e1r4mD4	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	1r4n	ZN	F	3	e1r4nF2	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	1r4n	ZN	H	4	e1r4nH2	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	1r4n	ZN	H	4	e1r4nH3	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	1r4n	ZN	J	2	e1r4nD1	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	1tt5	ZN	B	1014	e1tt5B1	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	1tt5	ZN	D	1014	e1tt5D1	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	1tt5	ZN	D	1014	e1tt5D3	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	1yov	ZN	B	443	e1yovB4	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	1yov	ZN	D	443	e1yovD2	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	2nvu	ZN	B	102	e2nvuB2	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	3dbh	ZN	B	1	e3dbhB1	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	3dbh	ZN	B	1	e3dbhB3	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	3dbh	ZN	D	3	e3dbhD1	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	3dbh	ZN	D	3	e3dbhD3	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	3dbh	ZN	F	4	e3dbhF1	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	3dbh	ZN	F	4	e3dbhF3	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	3dbh	ZN	H	2	e3dbhH1	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	3dbh	ZN	H	2	e3dbhH2	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	3dbl	ZN	B	1	e3dblB2	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	3dbl	ZN	D	3	e3dblD4	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	3dbl	ZN	F	4	e3dblF2	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	3dbl	ZN	F	4	e3dblF3	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	3dbl	ZN	H	2	e3dblH3	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	3dbl	ZN	H	2	e3dblH4	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	3dbr	ZN	B	1	e3dbrB1	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	3dbr	ZN	B	1	e3dbrB3	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	3dbr	ZN	D	3	e3dbrD1	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	3dbr	ZN	D	3	e3dbrD3	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	3dbr	ZN	F	4	e3dbrF1	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	3dbr	ZN	F	4	e3dbrF3	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	3dbr	ZN	H	2	e3dbrH1	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	3dbr	ZN	H	2	e3dbrH3	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	3gzn	ZN	B	465	e3gznB1	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	3gzn	ZN	B	465	e3gznB2	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF
Q8TBC4	n/a	3gzn	ZN	D	465	e3gznD1	beta-Grasp	E2-binding domain of E1	E2-binding domain of E1	E2_bind
Q8TBC4	n/a	3gzn	ZN	D	465	e3gznD2	Rossmann-like	Rossmann-related	Activating enzymes of the ubiquitin-like proteins	ThiF